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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans
|
|---|---|
| Published in |
Genome Biology, September 2015
|
| DOI | 10.1186/s13059-015-0748-4 |
| Pubmed ID | |
| Authors |
Robert Lowe, Marita G. Overhoff, Sreeram V. Ramagopalan, James C. Garbe, James Koh, Martha R. Stampfer, David H. Beach, Vardhman K. Rakyan, Cleo L. Bishop |
| Abstract |
Cellular senescence is a stable arrest of proliferation and is considered a key component of processes associated with carcinogenesis and other ageing-related phenotypes. Here, we perform methylome analysis of actively dividing and deeply senescent normal human epithelial cells. We identify senescence-associated differentially methylated positions (senDMPs) from multiple experiments using cells from one donor. We find that human senDMP epigenetic signatures are positively and significantly correlated with both cancer and ageing-associated methylation dynamics. We also identify germline genetic variants, including those associated with the p16INK4A locus, which are associated with the presence of in vivo senDMP signatures. Importantly, we also demonstrate that a single senDMP signature can be effectively reversed in a newly-developed protocol of transient senescence reversal. The senDMP signature has significant potential for understanding some of the key (epi)genetic etiological factors that may lead to cancer and age-related diseases in humans. |
X Demographics
The data shown below were collected from the profiles of 15 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 20% |
| United States | 2 | 13% |
| Canada | 1 | 7% |
| France | 1 | 7% |
| India | 1 | 7% |
| Unknown | 7 | 47% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 53% |
| Scientists | 5 | 33% |
| Science communicators (journalists, bloggers, editors) | 2 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Unknown | 73 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 20% |
| Researcher | 14 | 19% |
| Student > Master | 11 | 15% |
| Student > Bachelor | 7 | 9% |
| Lecturer | 4 | 5% |
| Other | 13 | 18% |
| Unknown | 10 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 24 | 32% |
| Biochemistry, Genetics and Molecular Biology | 23 | 31% |
| Medicine and Dentistry | 6 | 8% |
| Computer Science | 2 | 3% |
| Nursing and Health Professions | 1 | 1% |
| Other | 3 | 4% |
| Unknown | 15 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 February 2016.
All research outputs
#3,564,883
of 25,394,764 outputs
Outputs from Genome Biology
#2,466
of 4,470 outputs
Outputs of similar age
#45,664
of 283,886 outputs
Outputs of similar age from Genome Biology
#49
of 82 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,470 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 283,886 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.