Title |
A randomized, double-blind, placebo-controlled trial to assess the efficacy of topiramate in the treatment of post-traumatic stress disorder
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Published in |
BMC Psychiatry, May 2009
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DOI | 10.1186/1471-244x-9-28 |
Pubmed ID | |
Authors |
Marcelo Feijó Mello, Mary Sau Ling Yeh, Jair Barbosa Neto, Luciana Lorens Braga, Jose Paulo Fiks, Daniela Deise Mendes, Tais S Moriyama, Nina Leão Marques Valente, Mariana Caddrobi Pupo Costa, Patricia Mattos, Rodrigo Affonseca Bressan, Sergio Baxter Andreoli, Jair Jesus Mari |
Abstract |
Topiramate might be effective in the treatment of posttraumatic stress disorder (PTSD) because of its antikindling effect and its action in both inhibitory and excitatory neurotransmitters. Open-label studies and few controlled trials have suggested that this anticonvulsant may have therapeutic potential in PTSD. This 12-week randomized, double-blind, placebo-controlled clinical trial will compare the efficacy of topiramate with placebo and study the tolerability of topiramate in the treatment of PTSD. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 1% |
United States | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 88 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 15 | 16% |
Researcher | 14 | 15% |
Student > Master | 11 | 12% |
Professor | 7 | 8% |
Student > Doctoral Student | 6 | 7% |
Other | 20 | 22% |
Unknown | 18 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 28 | 31% |
Psychology | 20 | 22% |
Social Sciences | 5 | 5% |
Nursing and Health Professions | 4 | 4% |
Arts and Humanities | 3 | 3% |
Other | 9 | 10% |
Unknown | 22 | 24% |