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Early versus delayed cord clamping in small for gestational age infants and iron stores at 3 months of age - a randomized controlled trial

Overview of attention for article published in BMC Pediatrics, July 2018
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Title
Early versus delayed cord clamping in small for gestational age infants and iron stores at 3 months of age - a randomized controlled trial
Published in
BMC Pediatrics, July 2018
DOI 10.1186/s12887-018-1214-8
Pubmed ID
Authors

Abhishek Chopra, Anup Thakur, Pankaj Garg, Neelam Kler, Kanwal Gujral

Abstract

Delayed cord clamping is the standard of care in infants not requiring resuscitation; however effects of cord clamping strategies have not been evaluated systematically in small for gestational age (SGA) infants. The primary objective was to compare effects of delayed cord clamping (DCC) and early cord clamping (ECC) on serum ferritin at 3 months in SGA infants born at ≥35 weeks. The secondary objectives were to compare hematological parameters, clinical outcomes in neonatal period and growth at 3 months of age. All eligible infants with fetal growth restriction were randomized to two groups, DCC at 60 s or ECC group in which the cord was clamped immediately after birth. Total of 142 infants underwent randomization and subsequently 113 infants underwent definite inclusion. At 3 months, the median (IQR) serum ferritin levels were higher in DCC group, compared to ECC; 86 ng/ml (43.35-134.75) vs 50.5 ng/ml (29.5-83.5), p = 0.01. Fewer infants had iron deficiency in DCC group compared to ECC group; 9 (23.6%) vs 21 (47.7%), p = 0.03 [NNT being 4; 95% CI (2-25)].The proportion of infants with polycythemia was significantly higher in DCC group; 23 (41.81) % vs 12 (20.6%), p = 0.01. There was no difference in proportion of infants with symptomatic polycythemia or those who underwent partial exchange transfusions. Clinical outcomes and mortality were similar. DCC improves iron stores in SGA infants ≥35 weeks at 3 months of age without increasing the risk of symptomatic polycythemia, need for partial exchange transfusions or morbidities associated with polycythemia. Our trial was retrospectively registered on 29th May 2015 through Clinical trials registry India. Registration number: CTRI 2015/05/005828 .

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 123 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 123 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 20 16%
Student > Bachelor 16 13%
Student > Postgraduate 8 7%
Researcher 6 5%
Lecturer 5 4%
Other 11 9%
Unknown 57 46%
Readers by discipline Count As %
Medicine and Dentistry 32 26%
Nursing and Health Professions 19 15%
Biochemistry, Genetics and Molecular Biology 7 6%
Social Sciences 2 2%
Linguistics 1 <1%
Other 5 4%
Unknown 57 46%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 May 2019.
All research outputs
#20,527,576
of 23,096,849 outputs
Outputs from BMC Pediatrics
#2,644
of 3,052 outputs
Outputs of similar age
#287,707
of 329,171 outputs
Outputs of similar age from BMC Pediatrics
#75
of 81 outputs
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