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Mendeley readers
Attention Score in Context
| Title |
Lack of neuroinflammation in the HIV-1 transgenic rat: an [18F]-DPA714 PET imaging study
|
|---|---|
| Published in |
Journal of Neuroinflammation, September 2015
|
| DOI | 10.1186/s12974-015-0390-9 |
| Pubmed ID | |
| Authors |
Dianne E. Lee, Xuyi Yue, Wael G. Ibrahim, Margaret R. Lentz, Kristin L. Peterson, Elaine M. Jagoda, Michael Kassiou, Dragan Maric, William C. Reid, Dima A. Hammoud |
| Abstract |
HIV-associated neuroinflammation is believed to be a major contributing factor in the development of HIV-associated neurocognitive disorders (HAND). In this study, we used micropositron emission tomography (PET) imaging to quantify neuroinflammation in HIV-1 transgenic rat (Tg), a small animal model of HIV, known to develop neurological and behavioral problems. Dynamic [(18)F]DPA-714 PET imaging was performed in Tg and age-matched wild-type (WT) rats in three age groups: 3-, 9-, and 16-month-old animals. As a positive control for neuroinflammation, we performed unilateral intrastriatal injection of quinolinic acid (QA) in a separate group of WT rats. To confirm our findings, we performed multiplex immunofluorescent staining for Iba1 and we measured cytokine/chemokine levels in brain lysates of Tg and WT rats at different ages. [(18)F]DPA-714 uptake in HIV-1 Tg rat brains was generally higher than in age-matched WT rats but this was not statistically significant in any age group. [(18)F]DPA-714 uptake in the QA-lesioned rats was significantly higher ipsilateral to the lesion compared to contralateral side indicating neuroinflammatory changes. Iba1 immunofluorescence showed no significant differences in microglial activation between the Tg and WT rats, while the QA-lesioned rats showed significant activation. Finally, cytokine/chemokine levels in brain lysates of the Tg rats and WT rats were not significantly different. Microglial activation might not be the primary mechanism for neuropathology in the HIV-1 Tg rats. Although [(18)F]DPA-714 is a good biomarker of neuroinflammation, it cannot be reliably used as an in vivo biomarker of neurodegeneration in the HIV-1 Tg rat. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| South Africa | 1 | 2% |
| Unknown | 46 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 19% |
| Researcher | 8 | 17% |
| Student > Master | 6 | 13% |
| Professor > Associate Professor | 4 | 8% |
| Student > Bachelor | 3 | 6% |
| Other | 9 | 19% |
| Unknown | 9 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 21% |
| Agricultural and Biological Sciences | 6 | 13% |
| Neuroscience | 4 | 8% |
| Chemistry | 3 | 6% |
| Immunology and Microbiology | 2 | 4% |
| Other | 5 | 10% |
| Unknown | 18 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 October 2015.
All research outputs
#15,346,908
of 22,828,180 outputs
Outputs from Journal of Neuroinflammation
#1,751
of 2,630 outputs
Outputs of similar age
#159,364
of 272,396 outputs
Outputs of similar age from Journal of Neuroinflammation
#30
of 44 outputs
Altmetric has tracked 22,828,180 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,630 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 26th percentile – i.e., 26% of its peers scored the same or lower than it.
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We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.