Title |
Chi8: a GPU program for detecting significant interacting SNPs with the Chi-square 8-df test
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Published in |
BMC Research Notes, September 2015
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DOI | 10.1186/s13104-015-1392-5 |
Pubmed ID | |
Authors |
Abdulrhman Al-jouie, Mohammadreza Esfandiari, Srividya Ramakrishnan, Usman Roshan |
Abstract |
Determining interacting SNPs in genome-wide association studies is computationally expensive yet of considerable interest in genomics. We present a program Chi8 that calculates the Chi-square 8 degree of freedom test between all pairs of SNPs in a brute force manner on a Graphics Processing Unit. We analyze each of the seven WTCCC genome-wide association studies that have about 5000 total case and controls and 400,000 SNPs in an average of 9.6 h on a single GPU. We also study the power, false positives, and area under curve of our program on simulated data and provide a comparison to the GBOOST program. Our program source code is freely available from http://www.cs.njit.edu/usman/Chi8 . |
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