Title |
Safety and pharmacokinetics of recombinant human hepatocyte growth factor (rh-HGF) in patients with fulminant hepatitis: a phase I/II clinical trial, following preclinical studies to ensure safety
|
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Published in |
Journal of Translational Medicine, May 2011
|
DOI | 10.1186/1479-5876-9-55 |
Pubmed ID | |
Authors |
Akio Ido, Akihiro Moriuchi, Masatsugu Numata, Toshinori Murayama, Satoshi Teramukai, Hiroyuki Marusawa, Naohisa Yamaji, Hitoshi Setoyama, Il-Deok Kim, Tsutomu Chiba, Shuji Higuchi, Masayuki Yokode, Masanori Fukushima, Akira Shimizu, Hirohito Tsubouchi |
Abstract |
Hepatocyte growth factor (HGF) stimulates hepatocyte proliferation, and also acts as an anti-apoptotic factor. Therefore, HGF is a potential therapeutic agent for treatment of fatal liver diseases. We performed a translational medicine protocol with recombinant human HGF (rh-HGF), including a phase I/II study of patients with fulminant hepatitis (FH) or late-onset hepatic failure (LOHF), in order to examine the safety, pharmacokinetics, and clinical efficacy of this molecule. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Russia | 1 | 2% |
Unknown | 54 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 18 | 32% |
Student > Master | 7 | 13% |
Student > Ph. D. Student | 7 | 13% |
Other | 4 | 7% |
Student > Doctoral Student | 3 | 5% |
Other | 6 | 11% |
Unknown | 11 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 21 | 38% |
Agricultural and Biological Sciences | 7 | 13% |
Biochemistry, Genetics and Molecular Biology | 6 | 11% |
Nursing and Health Professions | 2 | 4% |
Immunology and Microbiology | 2 | 4% |
Other | 7 | 13% |
Unknown | 11 | 20% |