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Behavior of hyperreflective foci in non-infectious uveitic macular edema, a 12-month follow-up prospective study

Overview of attention for article published in BMC Ophthalmology, July 2018
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (84th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

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Title
Behavior of hyperreflective foci in non-infectious uveitic macular edema, a 12-month follow-up prospective study
Published in
BMC Ophthalmology, July 2018
DOI 10.1186/s12886-018-0848-5
Pubmed ID
Authors

Barbara Berasategui, Alex Fonollosa, Joseba Artaraz, Ioana Ruiz-Arruza, Jose Ríos, Jessica Matas, Victor Llorenç, David Diaz-Valle, Marina Sastre-Ibañez, Pedro Arriola-Villalobos, Alfredo Adan

Abstract

Hyperreflective foci have been described in OCT imaging of patients with retinal vascular diseases. It has been suggested that they may play a role as a prognostic factor of visual outcomes in these diseases. The purpose of this study is to describe the presence of hyperreflective foci in patients with non-infectious uveitic macular edema and evaluate their behavior after treatment. We conducted a multicenter, prospective, observational, 12-month follow-up study. Inclusion criteria were age > 18 years and a diagnosis of non-infectious uveitic macular edema, defined as central macular thickness of > 300 μm as measured by OCT and fluid in the macula. Collected data included best corrected visual acuity, central macular thickness and the presence, number and distribution (inner or outer retinal layers) of hyperreflective foci. Evaluations were performed at baseline, and at 1, 3, 6, and 12 months after starting treatment. We included 24 eyes of 24 patients. The frequency of patients with ≥11 hyperreflective foci was 58.4% at baseline, falling to 20.8% at 12 months. Further, hyperreflective foci were observed in the outer retinal layers in 50% of patients at baseline and just 28.6% at 12 months. Mean LogMAR visual acuity improved from 0.55 (95% CI 0.4-0.71) at baseline to 0.22 (95% CI 0.08-0.35) at 12 months (p < 0.001). Mean central macular thickness decreased from 453.83 μm (95% CI 396.6-511) at baseline to 269.32 μm (95% CI 227.7-310.9) at 12 months (P < 0.001). Central macular thickness was associated with number (p = 0.017) and distribution (p = 0.004) of hyperreflective foci. We have observed hyperreflective foci in most of our patients with non-infectious uveitic macular edema. During follow-up and after treatment, the number of foci diminished and they tended to be located in the inner layers of the retina.

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The data shown below were collected from the profiles of 17 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 16%
Other 4 13%
Student > Bachelor 4 13%
Student > Master 4 13%
Student > Doctoral Student 1 3%
Other 5 16%
Unknown 8 26%
Readers by discipline Count As %
Medicine and Dentistry 10 32%
Social Sciences 3 10%
Mathematics 2 6%
Immunology and Microbiology 2 6%
Biochemistry, Genetics and Molecular Biology 1 3%
Other 4 13%
Unknown 9 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2018.
All research outputs
#2,431,258
of 23,340,595 outputs
Outputs from BMC Ophthalmology
#99
of 2,461 outputs
Outputs of similar age
#51,345
of 329,540 outputs
Outputs of similar age from BMC Ophthalmology
#4
of 21 outputs
Altmetric has tracked 23,340,595 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,461 research outputs from this source. They receive a mean Attention Score of 2.7. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,540 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.