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Sympathetic Fibre Sprouting in the Skin Contributes to Pain-Related Behaviour in Spared Nerve Injury and Cuff Models of Neuropathic Pain

Overview of attention for article published in Molecular Pain, September 2015
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  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

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5 tweeters
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4 Facebook pages

Citations

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22 Dimensions

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43 Mendeley
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Title
Sympathetic Fibre Sprouting in the Skin Contributes to Pain-Related Behaviour in Spared Nerve Injury and Cuff Models of Neuropathic Pain
Published in
Molecular Pain, September 2015
DOI 10.1186/s12990-015-0062-x
Pubmed ID
Authors

Francisney P. Nascimento, Claire Magnussen, Noosha Yousefpour, Alfredo Ribeiro-da-Silva

Abstract

Cuff and spared nerve injury (SNI) in the sciatic territory are widely used to model neuropathic pain. Because nociceptive information is first detected in skin, it is important to understand how alterations in peripheral innervation contribute to pain in each model. Over 16 weeks in male rats, changes in sensory and autonomic innervation of the skin were described after cuff and SNI using immunohistochemistry to label myelinated (neurofilament 200 positive-NF200+) and peptidergic (calcitonin gene-related peptide positive-CGRP+) primary afferents and sympathetic fibres (dopamine β-hydroxylase positive-DBH+) Cuff and SNI caused an early loss and later reinnervation of NF200 and CGRP fibres in the plantar hind paw skin. In both models, DBH+ fibres sprouted into the upper dermis of the plantar skin 4 and 6 weeks after injury. Despite these similarities, behavioural pain measures were significantly different in each model. Sympathectomy using guanethidine significantly alleviated mechanical allodynia 6 weeks after cuff, when peak sympathetic sprouting was observed, having no effect at 2 weeks, when fibres were absent. In SNI animals, mechanical allodynia in the lateral paw was significantly improved by guanethidine at 2 and 6 weeks, and the development of cold hyperalgesia, which roughly paralleled the appearance of ectopic sympathetic fibres, was alleviated by guanethidine at 6 weeks. Sympathetic fibres did not sprout into the dorsal root ganglia at 2 or 6 weeks, indicating their unimportance to pain behaviour in these two models. Alterations in sympathetic innervation in the skin represents an important mechanism that contributes to pain in cuff and SNI models of neuropathic pain.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
France 1 2%
Unknown 41 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 26%
Student > Master 8 19%
Other 5 12%
Student > Bachelor 4 9%
Researcher 3 7%
Other 6 14%
Unknown 6 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 28%
Neuroscience 11 26%
Medicine and Dentistry 6 14%
Biochemistry, Genetics and Molecular Biology 5 12%
Social Sciences 1 2%
Other 2 5%
Unknown 6 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 October 2015.
All research outputs
#3,304,639
of 12,552,259 outputs
Outputs from Molecular Pain
#81
of 464 outputs
Outputs of similar age
#65,063
of 245,651 outputs
Outputs of similar age from Molecular Pain
#5
of 42 outputs
Altmetric has tracked 12,552,259 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 464 research outputs from this source. They receive a mean Attention Score of 3.2. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 245,651 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.