Title |
Why do patients get idiopathic pulmonary fibrosis? Current concepts in the pathogenesis of pulmonary fibrosis
|
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Published in |
BMC Medicine, September 2015
|
DOI | 10.1186/s12916-015-0412-6 |
Pubmed ID | |
Authors |
Pierre-Simon Bellaye, Martin Kolb |
Abstract |
Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease of unknown origin. Recent findings suggest that IPF results from multiple factors that eventually lead to interstitial lung injury. In the pathogenesis it is likely that complex relationships between genetic predispositions, environmental exposures, and lung infections promote the fibrotic processes causing IPF; it is this complexity and the multiplicity of causes that make the population and clinical course of IPF so heterogeneous. Thus, it is clear that one common factor driving IPF pathogenesis in all patients would be far too simplified of an understanding. In recent years, efforts have been made in finding therapeutic strategies that target disease progression rather than disease onset. The biochemical composition and abnormal stiffness of the matrix might be crucial in controlling the cellular phenotype in fibrotic lungs that promotes disease progression and persistence. Though there has been substantial progress in the IPF field in recent years, much more work is required in order to improve the prognosis associated with this disease. |
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Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
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United States | 1 | 2% |
Germany | 1 | 2% |
Unknown | 52 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 9 | 17% |
Other | 7 | 13% |
Researcher | 6 | 11% |
Professor | 4 | 7% |
Student > Ph. D. Student | 4 | 7% |
Other | 10 | 19% |
Unknown | 14 | 26% |
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Agricultural and Biological Sciences | 6 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
Nursing and Health Professions | 1 | 2% |
Other | 6 | 11% |
Unknown | 19 | 35% |