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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity
|
|---|---|
| Published in |
Retrovirology, September 2015
|
| DOI | 10.1186/s12977-015-0210-4 |
| Pubmed ID | |
| Authors |
Kwinten Sliepen, Gabriel Ozorowski, Judith A. Burger, Thijs van Montfort, Melissa Stunnenberg, Celia LaBranche, David C. Montefiori, John P. Moore, Andrew B. Ward, Rogier W. Sanders |
| Abstract |
Presenting vaccine antigens in particulate form can improve their immunogenicity by enhancing B cell activation. We describe ferritin-based protein nanoparticles that display multiple copies of native-like HIV-1 envelope glycoprotein trimers (BG505 SOSIP.664). Trimer-bearing nanoparticles were significantly more immunogenic than trimers in both mice and rabbits. Furthermore, rabbits immunized with the trimer-bearing nanoparticles induced significantly higher neutralizing antibody responses against most tier 1A viruses, and higher responses (but not significantly), to several tier 1B viruses and the autologous tier 2 virus than when the same trimers were delivered as soluble proteins. This or other nanoparticle designs may be practical ways to improve the immunogenicity of envelope glycoprotein trimers. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ireland | 1 | 14% |
| United States | 1 | 14% |
| United Kingdom | 1 | 14% |
| Unknown | 4 | 57% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 86% |
| Science communicators (journalists, bloggers, editors) | 1 | 14% |
Mendeley readers
The data shown below were compiled from readership statistics for 151 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Unknown | 149 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 42 | 28% |
| Researcher | 20 | 13% |
| Student > Master | 18 | 12% |
| Student > Bachelor | 15 | 10% |
| Professor | 7 | 5% |
| Other | 12 | 8% |
| Unknown | 37 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 35 | 23% |
| Agricultural and Biological Sciences | 33 | 22% |
| Immunology and Microbiology | 21 | 14% |
| Medicine and Dentistry | 5 | 3% |
| Engineering | 5 | 3% |
| Other | 18 | 12% |
| Unknown | 34 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 56. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 March 2024.
All research outputs
#763,608
of 25,613,746 outputs
Outputs from Retrovirology
#23
of 1,274 outputs
Outputs of similar age
#10,878
of 287,351 outputs
Outputs of similar age from Retrovirology
#1
of 23 outputs
Altmetric has tracked 25,613,746 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,274 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 287,351 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.