Title |
Epigenetic silencing of a long non-coding RNA KIAA0495 in multiple myeloma
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Published in |
Molecular Cancer, September 2015
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DOI | 10.1186/s12943-015-0444-8 |
Pubmed ID | |
Authors |
Kwan Yeung Wong, Zhenhai Li, Xiaoqin Zhang, Gilberto Ka Kit Leung, Godfrey Chi-fung Chan, Chor Sang Chim |
Abstract |
In multiple myeloma, a long non-coding RNA, KIAA0495 (alias PDAM/TP73-AS1), had been found progressively downregulated from normal plasma cell to benign monoclonal gammopathy of undetermined significance to symptomatic myeloma. Herein, by methylation-specific PCR, the putative KIAA0495 promoter was found unmethylated in all healthy controls (N = 14) but methylated in 50 % of myeloma cell lines (N = 10). KIAA0495 methylation was shown inversely correlated with KIAA0495 expression. However, KIAA0495 methylation was detected in none of both primary myeloma samples at diagnosis (N = 61) and at relapse/progression (N = 16). Collectively, despite frequently methylated in cell lines, KIAA0495 methylation appeared unimportant in the pathogenesis or progression of myeloma. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 50% |
France | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 2 | 50% |
Members of the public | 2 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 19 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 26% |
Researcher | 5 | 26% |
Other | 2 | 11% |
Student > Doctoral Student | 1 | 5% |
Professor | 1 | 5% |
Other | 3 | 16% |
Unknown | 2 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 37% |
Biochemistry, Genetics and Molecular Biology | 3 | 16% |
Neuroscience | 2 | 11% |
Agricultural and Biological Sciences | 2 | 11% |
Unspecified | 1 | 5% |
Other | 2 | 11% |
Unknown | 2 | 11% |