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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Poly- and autoreactivity of HIV-1 bNAbs: implications for vaccine design
|
|---|---|
| Published in |
Retrovirology, July 2018
|
| DOI | 10.1186/s12977-018-0435-0 |
| Pubmed ID | |
| Authors |
Joel Finney, Garnett Kelsoe |
| Abstract |
A central puzzle in HIV-1 research is the inability of vaccination or even infection to reliably elicit humoral responses against broadly neutralizing epitopes in the HIV-1 envelope protein. In infected individuals, broadly neutralizing antibodies (bNAbs) do arise in a substantial minority, but only after 2 or more years of chronic infection. All known bNAbs possess at least one of three traits: a high frequency of somatic hypermutation, a long third complementarity determining region in the antibody heavy chain (HCDR3), or significant poly- or autoreactivity. Collectively, these observations suggest a plausible explanation for the rarity of many types of bNAbs: namely, that their generation is blocked by immunological tolerance or immune response checkpoints, thereby mandating that B cells take a tortuous path of somatic evolution over several years to achieve broadly neutralizing activity. In this brief review, we discuss the evidence for this tolerance hypothesis, its implications for HIV-1 vaccine design, and potential ways to access normally forbidden compartments of the antibody repertoire by modulating or circumventing tolerance controls. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 33% |
| Australia | 1 | 17% |
| United Kingdom | 1 | 17% |
| Unknown | 2 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 33% |
| Science communicators (journalists, bloggers, editors) | 2 | 33% |
| Members of the public | 2 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 42 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 21% |
| Researcher | 7 | 17% |
| Student > Bachelor | 5 | 12% |
| Student > Master | 4 | 10% |
| Student > Doctoral Student | 2 | 5% |
| Other | 2 | 5% |
| Unknown | 13 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 10 | 24% |
| Biochemistry, Genetics and Molecular Biology | 5 | 12% |
| Agricultural and Biological Sciences | 5 | 12% |
| Chemical Engineering | 3 | 7% |
| Medicine and Dentistry | 3 | 7% |
| Other | 3 | 7% |
| Unknown | 13 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 September 2018.
All research outputs
#12,910,385
of 23,098,660 outputs
Outputs from Retrovirology
#556
of 1,110 outputs
Outputs of similar age
#154,168
of 330,143 outputs
Outputs of similar age from Retrovirology
#11
of 21 outputs
Altmetric has tracked 23,098,660 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,110 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,143 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.