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The role of IL‐33 and mast cells in allergy and inflammation

Overview of attention for article published in Clinical and Translational Allergy, September 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)

Mentioned by

blogs
1 blog
twitter
11 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
136 Dimensions

Readers on

mendeley
175 Mendeley
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Title
The role of IL‐33 and mast cells in allergy and inflammation
Published in
Clinical and Translational Allergy, September 2015
DOI 10.1186/s13601-015-0076-5
Pubmed ID
Authors

Rohit Saluja, Mahejibin Khan, Martin K. Church, Marcus Maurer

Abstract

Interleukin-33 (IL-33) is a member of the interleukin-1 (IL-1) cytokine family. It is preferentially and constitutively expressed in different structural cells such as epithelial cells, endothelial cells, and smooth muscle cells. During necrosis of these cells (after tissue injury or cell damage), the IL-33 that is released may be recognized by different types of immune cells, such as eosinophils, basophils and, especially, mast cells. IL-33 needs the specific receptor ST2 (membrane-bound receptor) and Interleukin-1 receptor accessory protein heterodimer for its binding, which instigates the production of different types of cytokines and chemokines that have crucial roles in the exacerbation of allergic diseases and inflammation. IL-33 and mast cells have been influentially associated to the pathophysiology of allergic diseases and inflammation. IL-33 is a crucial regulator of mast cell functions and might be an attractive therapeutic target for the treatment of allergic and inflammatory diseases. In this review, we summarize the current knowledge regarding the roles of IL-33 and mast cells in the pathogenesis of allergies and inflammation.

Twitter Demographics

The data shown below were collected from the profiles of 11 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 175 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 <1%
Brazil 1 <1%
Unknown 173 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 38 22%
Student > Master 26 15%
Researcher 23 13%
Student > Bachelor 18 10%
Student > Doctoral Student 13 7%
Other 27 15%
Unknown 30 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 34 19%
Medicine and Dentistry 32 18%
Immunology and Microbiology 31 18%
Biochemistry, Genetics and Molecular Biology 22 13%
Pharmacology, Toxicology and Pharmaceutical Science 9 5%
Other 7 4%
Unknown 40 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 April 2016.
All research outputs
#1,797,627
of 17,997,558 outputs
Outputs from Clinical and Translational Allergy
#95
of 529 outputs
Outputs of similar age
#31,468
of 258,428 outputs
Outputs of similar age from Clinical and Translational Allergy
#1
of 1 outputs
Altmetric has tracked 17,997,558 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 529 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.7. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 258,428 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them