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Malignant teratoma in Klippel–Feil syndrome: a case report and review of the literature

Overview of attention for article published in Journal of Medical Case Reports, October 2015
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Title
Malignant teratoma in Klippel–Feil syndrome: a case report and review of the literature
Published in
Journal of Medical Case Reports, October 2015
DOI 10.1186/s13256-015-0700-y
Pubmed ID
Authors

A. Adorno, C. Alafaci, F. Sanfilippo, D. Cafarella, M. Scordino, F. Granata, G. Grasso, F M Salpietro

Abstract

Klippel-Feil syndrome is characterized by a congenital fusion of cervical vertebrae. Intracranial teratomas are nongerminomatous germ cell tumors and they account for 0.3 to 0.9% of all intracranial tumors. Teratomas with malignant transformation refer to lesions which give rise to malignant cancer of somatic type. The association between tumors of dermoid origin and Klippel-Feil malformation is extremely rare. Only 23 other cases have so far been reported, and only one case of dermoid tumor with areas of dedifferentiation on squamous cell carcinoma has been described. We report the case of a 72-year-old white man with a 2-year history of gait and balance disturbances. A brain magnetic resonance imaging revealed a fourth ventricle neoplastic process with infiltrative features. He was operated through a suboccipital craniectomy with a C1 laminotomy and bilateral vertebral artery transposition. At 6-months follow-up, magnetic resonance imaging showed an early regrowth of the fourth ventricle tumor, with the same radiological features. Patients with Klippel-Feil malformation could develop posterior fossa dermoid tumors. The malignant potential of such tumors must be considered and surgery is recommended. Particular attention must be focused on the histopathological analysis in order to identify possible foci of malignant transformation.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 6 24%
Student > Ph. D. Student 3 12%
Professor 2 8%
Researcher 2 8%
Student > Postgraduate 2 8%
Other 5 20%
Unknown 5 20%
Readers by discipline Count As %
Medicine and Dentistry 10 40%
Neuroscience 2 8%
Sports and Recreations 2 8%
Nursing and Health Professions 1 4%
Arts and Humanities 1 4%
Other 1 4%
Unknown 8 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 October 2015.
All research outputs
#18,428,159
of 22,829,683 outputs
Outputs from Journal of Medical Case Reports
#2,257
of 3,919 outputs
Outputs of similar age
#199,438
of 277,201 outputs
Outputs of similar age from Journal of Medical Case Reports
#29
of 60 outputs
Altmetric has tracked 22,829,683 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
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