Title |
YY1 overexpression is associated with poor prognosis and metastasis-free survival in patients suffering osteosarcoma
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Published in |
BMC Cancer, November 2011
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DOI | 10.1186/1471-2407-11-472 |
Pubmed ID | |
Authors |
Filomena de Nigris, Licciana Zanella, Francesco Cacciatore, Anna De Chiara, Flavio Fazioli, Gennaro Chiappetta, Gaetano Apice, Teresa Infante, Mario Monaco, Raffaele Rossiello, Gaetano De Rosa, Marco Alberghini, Claudio Napoli |
Abstract |
The polycomb transcription factor Yin Yang 1 (YY1) overexpression can be causally implicated in experimental tumor growth and metastasization. To date, there is no clinical evidence of YY1 involvement in outcome of patients with osteosarcoma. Prognosis of osteosarcoma is still severe and only few patients survive beyond five years. We performed a prospective immunohistochemistry analysis to correlate YY1 immunostaining with metastatic development and survival in a selected homogeneous group of patients with osteosarcoma. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Poland | 1 | 3% |
Unknown | 32 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 9 | 27% |
Student > Ph. D. Student | 4 | 12% |
Other | 2 | 6% |
Researcher | 2 | 6% |
Student > Postgraduate | 2 | 6% |
Other | 6 | 18% |
Unknown | 8 | 24% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 8 | 24% |
Medicine and Dentistry | 7 | 21% |
Agricultural and Biological Sciences | 4 | 12% |
Chemistry | 2 | 6% |
Arts and Humanities | 1 | 3% |
Other | 2 | 6% |
Unknown | 9 | 27% |