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Effects of melatonin on the nitric oxide system and protein nitration in the hypobaric hypoxic rat hippocampus

Overview of attention for article published in BMC Neuroscience, October 2015
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Title
Effects of melatonin on the nitric oxide system and protein nitration in the hypobaric hypoxic rat hippocampus
Published in
BMC Neuroscience, October 2015
DOI 10.1186/s12868-015-0199-6
Pubmed ID
Authors

Chih-Chia Huang, Chia-Jou Lai, Mang-Hung Tsai, Ya-Chieh Wu, Kuang-Ti Chen, Ming-Jia Jou, Pin-I Fu, Ching-Hsiang Wu, I-Hua Wei

Abstract

It is well documented that the nitric oxide (NO) might be directly involved in brain response to hypobaric hypoxia, and could contribute to memory deficiencies. Recent studies have shown that melatonin could attenuate hypoxia or ischemia-induced nerve injuries by decreasing the production of free radicals. The present study, using immunohistochemical and immunoblot methods, aimed to explore whether melatonin treatment may affect the expression of nitric oxide system and protein nitration, and provide neuroprotection in the rat hippocampus injured by hypobaric hypoxia. Prior to hypoxic treatment, adult rats were pretreated with melatonin (100 mg/kg, i.p.) before they were exposed to the altitude chamber with 48 Torr of the partial oxygen concentration (pO2) for 7 h to mimic the ambience of being at 9000 m in height. They were then sacrificed after 0 h, 1, and 3 days of reoxygenation. The results obtained from the immunohistochemical and immunoblotting analyses showed that the expressions of neuronal nitric oxide synthase (nNOS), endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), nitrotyrosine (Ntyr) and Caspase 3 in the hypoxic hippocampus were increased from 0 h to 3 days of reoxygenation. Interestingly, the hypoxia-induced increase of nNOS, eNOS, iNOS, Ntyr and Caspase 3 protein expression was significantly depressed in the hypoxic rats treated with melatonin. Activation of the nitric oxide system and protein nitration constitutes a hippocampal response to hypobaric hypoxia and administration of melatonin could provide new therapeutic avenues to prevent and/or treat the symptoms produced by hypobaric hypoxia.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 21%
Student > Ph. D. Student 4 17%
Student > Master 3 13%
Student > Doctoral Student 3 13%
Professor 1 4%
Other 3 13%
Unknown 5 21%
Readers by discipline Count As %
Medicine and Dentistry 5 21%
Biochemistry, Genetics and Molecular Biology 3 13%
Neuroscience 3 13%
Agricultural and Biological Sciences 2 8%
Psychology 1 4%
Other 3 13%
Unknown 7 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 October 2015.
All research outputs
#10,132,511
of 11,426,369 outputs
Outputs from BMC Neuroscience
#794
of 946 outputs
Outputs of similar age
#202,272
of 247,303 outputs
Outputs of similar age from BMC Neuroscience
#23
of 28 outputs
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