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Implications of population-level immunity for the emergence of artemisinin-resistant malaria: a mathematical model

Overview of attention for article published in Malaria Journal, August 2018
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

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1 policy source
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26 X users

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86 Mendeley
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Title
Implications of population-level immunity for the emergence of artemisinin-resistant malaria: a mathematical model
Published in
Malaria Journal, August 2018
DOI 10.1186/s12936-018-2418-y
Pubmed ID
Authors

Nick Scott, Ricardo Ataide, David P. Wilson, Margaret Hellard, Ric N. Price, Julie A. Simpson, Freya J. I. Fowkes

Abstract

Artemisinin-resistant Plasmodium falciparum has emerged in the Greater Mekong Subregion, an area of relatively low transmission, but has yet to be reported in Africa. A population-based mathematical model was used to investigate the relationship between P. falciparum prevalence, exposure-acquired immunity and time-to-emergence of artemisinin resistance. The possible implication for the emergence of resistance across Africa was assessed. The model included human and mosquito populations, two strains of malaria ("wild-type", "mutant"), three levels of human exposure-acquired immunity (none, low, high) with two types of immunity for each level (sporozoite/liver stage immunity and blood-stage/gametocyte immunity) and drug pressure based on per-capita treatment numbers. The model predicted that artemisinin-resistant strains may circulate up to 10 years longer in high compared to low P. falciparum prevalence areas before resistance is confirmed. Decreased time-to-resistance in low prevalence areas was explained by low genetic diversity and immunity, which resulted in increased probability of selection and spread of artemisinin-resistant strains. Artemisinin resistance was estimated to be established by 2020 in areas of Africa with low (< 10%) P. falciparum prevalence, but not for 5 or 10 years later in moderate (10-25%) or high (> 25%) prevalence areas, respectively. Areas of low transmission and low immunity give rise to a more rapid expansion of artemisinin-resistant parasites, corroborating historical observations of anti-malarial resistance emergence. Populations where control strategies are in place that reduce malaria transmission, and hence immunity, may be prone to a rapid emergence and spread of artemisinin-resistant strains and thus should be carefully monitored.

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X Demographics

X Demographics

The data shown below were collected from the profiles of 26 X users who shared this research output. Click here to find out more about how the information was compiled.
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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 86 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 17%
Researcher 14 16%
Student > Master 10 12%
Student > Doctoral Student 5 6%
Student > Bachelor 5 6%
Other 10 12%
Unknown 27 31%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 13%
Medicine and Dentistry 11 13%
Biochemistry, Genetics and Molecular Biology 10 12%
Pharmacology, Toxicology and Pharmaceutical Science 5 6%
Nursing and Health Professions 3 3%
Other 14 16%
Unknown 32 37%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 19. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 February 2023.
All research outputs
#2,051,139
of 26,290,653 outputs
Outputs from Malaria Journal
#344
of 6,111 outputs
Outputs of similar age
#39,569
of 345,262 outputs
Outputs of similar age from Malaria Journal
#4
of 99 outputs
Altmetric has tracked 26,290,653 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,111 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 345,262 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 99 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.