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Evaluation of carbapenem resistance using phenotypic and genotypic techniques in Enterobacteriaceae isolates

Overview of attention for article published in Annals of Clinical Microbiology and Antimicrobials, October 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (66th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

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6 X users

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Title
Evaluation of carbapenem resistance using phenotypic and genotypic techniques in Enterobacteriaceae isolates
Published in
Annals of Clinical Microbiology and Antimicrobials, October 2015
DOI 10.1186/s12941-015-0105-1
Pubmed ID
Authors

Kazım Sahin, Ayse Tekin, Sule Ozdas, Demet Akin, Hande Yapislar, Aziz Ramazan Dilek, Emine Sonmez

Abstract

Bacterial resistance to antibiotics is increasing worldwide. Antibiotic-resistant strains can lead to serious problems regarding treatment of infection. Carbapenem antibiotics are the final treatment option for infections caused by serious and life-threatening multidrug-resistant gram-negative bacteria. Therefore, an understanding of carbapenem resistance is important for infection control. In the study described herein, the phenotypic and genotypic features of carbapenem-resistant Enterobacteriaceae strains isolated in our hospital were evaluated. In total, 43 carbapenem-resistant strains were included in this study. Sensitivity to antibiotics was determined using the VITEK(®)2 system. The modified Hodge test (MHT) and metallo-β-lactamase (MBL) antimicrobial gradient test were performed for phenotypic identification. Resistance genes IMP, VIM, KPC, NDM-1, and OXA-48 were amplified by multiplex PCR. The OXA-48 gene was detected in seven strains, and the NDM-1 gene in one strain. No resistance genes were detected in the remainder of strains. A significant correlation was observed between the MHT test and OXA-48 positivity, and between the MBL antimicrobial gradient test and positivity for resistance genes (p < 0.05). The finding of one NDM-1-positive isolate in this study indicates that carbapenem resistance is spreading in Turkey. Carbapenem resistance spreads rapidly and causes challenges in treatment, and results in high mortality/morbidity rates. Therefore, is necessary to determine carbapenem resistance in Enterobacteriaceae isolates and to take essential infection control precautions to avoid spread of this resistance.

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X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 89 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Unknown 88 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 16%
Researcher 14 16%
Student > Bachelor 9 10%
Student > Postgraduate 9 10%
Student > Doctoral Student 8 9%
Other 16 18%
Unknown 19 21%
Readers by discipline Count As %
Medicine and Dentistry 23 26%
Immunology and Microbiology 13 15%
Biochemistry, Genetics and Molecular Biology 11 12%
Agricultural and Biological Sciences 8 9%
Pharmacology, Toxicology and Pharmaceutical Science 2 2%
Other 10 11%
Unknown 22 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 October 2015.
All research outputs
#7,367,974
of 22,829,683 outputs
Outputs from Annals of Clinical Microbiology and Antimicrobials
#157
of 608 outputs
Outputs of similar age
#92,406
of 277,991 outputs
Outputs of similar age from Annals of Clinical Microbiology and Antimicrobials
#2
of 8 outputs
Altmetric has tracked 22,829,683 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 608 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,991 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.