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Mendeley readers
Attention Score in Context
| Title |
Genetics ignite focus on microglial inflammation in Alzheimer’s disease
|
|---|---|
| Published in |
Molecular Neurodegeneration, October 2015
|
| DOI | 10.1186/s13024-015-0048-1 |
| Pubmed ID | |
| Authors |
Manasi Malik, Ishita Parikh, Jared B. Vasquez, Conor Smith, Leon Tai, Guojun Bu, Mary Jo LaDu, David W. Fardo, G. William Rebeck, Steven Estus |
| Abstract |
In the past five years, a series of large-scale genetic studies have revealed novel risk factors for Alzheimer's disease (AD). Analyses of these risk factors have focused attention upon the role of immune processes in AD, specifically microglial function. In this review, we discuss interpretation of genetic studies. We then focus upon six genes implicated by AD genetics that impact microglial function: TREM2, CD33, CR1, ABCA7, SHIP1, and APOE. We review the literature regarding the biological functions of these six proteins and their putative role in AD pathogenesis. We then present a model for how these factors may interact to modulate microglial function in AD. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 50% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 266 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 2% |
| United Kingdom | 2 | <1% |
| Denmark | 1 | <1% |
| France | 1 | <1% |
| Unknown | 258 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 57 | 21% |
| Student > Ph. D. Student | 50 | 19% |
| Student > Bachelor | 30 | 11% |
| Student > Master | 29 | 11% |
| Student > Doctoral Student | 14 | 5% |
| Other | 34 | 13% |
| Unknown | 52 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 65 | 24% |
| Biochemistry, Genetics and Molecular Biology | 42 | 16% |
| Agricultural and Biological Sciences | 36 | 14% |
| Medicine and Dentistry | 27 | 10% |
| Immunology and Microbiology | 11 | 4% |
| Other | 29 | 11% |
| Unknown | 56 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 103. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 July 2022.
All research outputs
#345,814
of 22,962,258 outputs
Outputs from Molecular Neurodegeneration
#7
of 852 outputs
Outputs of similar age
#5,289
of 277,912 outputs
Outputs of similar age from Molecular Neurodegeneration
#1
of 19 outputs
Altmetric has tracked 22,962,258 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 852 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.3. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,912 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.