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Abrogation of contaminating RNA activity in HIV-1 Gag VLPs

Overview of attention for article published in Virology Journal, October 2011
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39 Mendeley
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Title
Abrogation of contaminating RNA activity in HIV-1 Gag VLPs
Published in
Virology Journal, October 2011
DOI 10.1186/1743-422x-8-462
Pubmed ID
Authors

Ziyaad Valley-Omar, Ann E Meyers, Enid G Shephard, Anna-Lise Williamson, Edward P Rybicki

Abstract

HIV-1 Gag virus like particles (VLPs) used as candidate vaccines are regarded as inert particles as they contain no replicative nucleic acid, although they do encapsidate cellular RNAs. During HIV-1 Gag VLP production in baculovirus-based expression systems, VLPs incorporate the baculovirus Gp64 envelope glycoprotein, which facilitates their entry into mammalian cells. This suggests that HIV-1 Gag VLPs produced using this system facilitate uptake and subsequent expression of encapsidated RNA in mammalian cells - an unfavourable characteristic for a vaccine.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
Argentina 1 3%
Unknown 37 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 28%
Researcher 8 21%
Student > Master 4 10%
Student > Bachelor 3 8%
Student > Postgraduate 3 8%
Other 6 15%
Unknown 4 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 23%
Immunology and Microbiology 6 15%
Biochemistry, Genetics and Molecular Biology 6 15%
Medicine and Dentistry 5 13%
Nursing and Health Professions 1 3%
Other 5 13%
Unknown 7 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 October 2018.
All research outputs
#14,657,483
of 23,923,788 outputs
Outputs from Virology Journal
#1,547
of 3,153 outputs
Outputs of similar age
#89,358
of 136,210 outputs
Outputs of similar age from Virology Journal
#39
of 76 outputs
Altmetric has tracked 23,923,788 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,153 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.7. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 136,210 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 76 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.