Title |
An in vivo animal study assessing long-term changes in hypothalamic cytokines following perinatal exposure to a chemical mixture based on Arctic maternal body burden
|
---|---|
Published in |
Environmental Health, July 2011
|
DOI | 10.1186/1476-069x-10-65 |
Pubmed ID | |
Authors |
Shawn Hayley, Emily Mangano, Geoffrey Crowe, Nanqin Li, Wayne J Bowers |
Abstract |
The geographic distribution of environmental toxins is generally not uniform, with certain northern regions showing a particularly high concentration of pesticides, heavy metals and persistent organic pollutants. For instance, Northern Canadians are exposed to high levels of persistent organic pollutants like polychlorinated biphenyls (PCB), organochlorine pesticides (OCs) and methylmercury (MeHg), primarily through country foods. Previous studies have reported associations between neuronal pathology and exposure to such toxins. The present investigation assessed whether perinatal exposure (gestation and lactation) of rats to a chemical mixture (27 constituents comprised of PCBs, OCs and MeHg) based on Arctic maternal exposure profiles at concentrations near human exposure levels, would affect brain levels of several inflammatory cytokines |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 2% |
United States | 1 | 2% |
Canada | 1 | 2% |
Unknown | 59 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 12 | 19% |
Student > Ph. D. Student | 11 | 18% |
Researcher | 10 | 16% |
Student > Bachelor | 9 | 15% |
Professor | 3 | 5% |
Other | 6 | 10% |
Unknown | 11 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 24% |
Agricultural and Biological Sciences | 11 | 18% |
Neuroscience | 4 | 6% |
Environmental Science | 3 | 5% |
Nursing and Health Professions | 3 | 5% |
Other | 11 | 18% |
Unknown | 15 | 24% |