Title |
Functional implications of Rab27 GTPases in Cancer
|
---|---|
Published in |
Cell Communication and Signaling, August 2018
|
DOI | 10.1186/s12964-018-0255-9 |
Pubmed ID | |
Authors |
Zhihong Li, Rui Fang, Jia Fang, Shasha He, Tang Liu |
Abstract |
The Rab27 family of small GTPases promotes the progression of breast cancer, melanoma, and other human cancers. In this review, we discuss the role of Rab27 GTPases in cancer progression and the potential applications of these targets in cancer treatment. Elevated expression of Rab27 GTPases is associated with poor prognosis and cancer metastasis. Moreover, these GTPases govern a variety of oncogenic functions, including cell proliferation, cell motility, and chemosensitivity. In addition, small GTPases promote tumor growth and metastasis by enhancing exosome secretion, which alters intracellular microRNA levels, signaling molecule expression, and the tumor microenvironment. Rab27 GTPases may have applications as prognostic markers and therapeutic targets in cancer treatment. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 73 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 11 | 15% |
Student > Ph. D. Student | 10 | 14% |
Student > Master | 9 | 12% |
Researcher | 5 | 7% |
Student > Doctoral Student | 4 | 5% |
Other | 6 | 8% |
Unknown | 28 | 38% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 18 | 25% |
Medicine and Dentistry | 7 | 10% |
Agricultural and Biological Sciences | 6 | 8% |
Immunology and Microbiology | 4 | 5% |
Chemistry | 3 | 4% |
Other | 6 | 8% |
Unknown | 29 | 40% |