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Exploring the associations between systemic inflammation, obesity and healthy days: a health related quality of life (HRQOL) analysis of NHANES 2005–2008

Overview of attention for article published in BMC Obesity, August 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (60th percentile)

Mentioned by

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6 tweeters

Citations

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10 Dimensions

Readers on

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29 Mendeley
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Title
Exploring the associations between systemic inflammation, obesity and healthy days: a health related quality of life (HRQOL) analysis of NHANES 2005–2008
Published in
BMC Obesity, August 2018
DOI 10.1186/s40608-018-0196-2
Pubmed ID
Authors

Jeffrey Wilkins, Palash Ghosh, Juan Vivar, Bibhas Chakraborty, Sujoy Ghosh

Abstract

Obesity is positively associated with low-level chronic inflammation, and negatively associated with several indices of health-related quality of life (HRQOL). It is however not clear if obesity-associated inflammation is partly responsible for the observed negative associations between obesity and HRQOL, and also whether systemic inflammation independently affects HRQOL. We conducted an exploratory analysis to investigate the relationships between obesity, systemic inflammation and indices of HRQOL, using NHANES survey data. Data for the variables of interest were available for 6325 adults (aged 20-75 years, BMI > 18.5 kg/m2). Demographic, body mass index (BMI), C-reactive protein (CRP), inflammatory disease status, medication use, smoking, and HRQOL data were obtained from NHANES (2005-2008) and analyzed using sampling-weighted generalized linear models. Data was subjected to multiple imputation in order to mitigate information loss from survey non-response. Both main effects and interaction effects were analyzed to evaluate possible mediation or moderation effects. Model robustness was ascertained via sensitivity analysis. Averaged results from the imputed datasets were reported in as odds ratios (OR) and confidence intervals (CI). Obesity was positively associated with poor physical healthy days (OR: 1.59, 95% CI: 1.15-2.21) in unadjusted models. 'Elevated' and 'clinically raised' levels of the inflammation marker CRP were also positively associated with poor physical healthy days (OR = 1.61, 95% CI: 1.23-2.12, and OR = 2.45, 95% CI: 1.84-3.26, respectively); additionally, 'clinically raised' CRP was positively associated with mental unhealthy days (OR = 1.66, 95% CI: 1.26-2.19). The association between obesity and physical HRQOL was rendered non-significant in models including CRP. Association between 'elevated' and 'clinically raised' CRP and physical unhealthy days remained significant even after adjustment for obesity or inflammation-modulating covariates (OR = 1.36, 95% CI: 1.02-1.82, and OR = 1.75, 95% CI: 1.21-2.54, respectively). Systemic inflammation appears to mediate the association between obesity and physical unhealthy days. Clinically raised inflammation is an independent determinant of physical and mental unhealthy days. Importantly, elevated (but sub-clinical) inflammation is also negatively associated with physical healthy days, and may warrant more attention from a population health perspective than currently appreciated.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 29 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 17%
Student > Ph. D. Student 4 14%
Student > Master 3 10%
Other 2 7%
Professor 2 7%
Other 7 24%
Unknown 6 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 17%
Psychology 4 14%
Medicine and Dentistry 4 14%
Nursing and Health Professions 3 10%
Agricultural and Biological Sciences 2 7%
Other 4 14%
Unknown 7 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 September 2021.
All research outputs
#6,148,130
of 19,069,422 outputs
Outputs from BMC Obesity
#89
of 182 outputs
Outputs of similar age
#113,308
of 290,974 outputs
Outputs of similar age from BMC Obesity
#1
of 1 outputs
Altmetric has tracked 19,069,422 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 182 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.8. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 290,974 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them