Title |
Comparative bactericidal activity of four fluoroquinolones against Pseudomonas aeruginosa isolated from chronic suppurative otitis media
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Published in |
BMC Ear, Nose and Throat Disorders, October 2015
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DOI | 10.1186/s12901-015-0018-9 |
Pubmed ID | |
Authors |
Katsuhisa Ikeda, Shigeki Misawa, Takeshi Kusunoki |
Abstract |
The aim of the present study was to evaluate the bactericidal activity of four new fluoroquinolones against current isolates of Pseudomonas aeruginosa from the patients with chronic suppurative otitis media (CSOM). We examined bactericidal activity of four types of fluoroquinolones, garenoxacin (GRNX), levofloxacin (LVFX), ciprofloxacin (CPFX) and sitafloxacin (STFX) against current isolates of P. aeruginosa (50 strains). STFX exhibited the most potent activity of both MIC50 and MIC90, followed by CPFX, LVFX, and GRNX. The number of GRNX-resistant strains was significantly greater than those of LVFX, CPFX, and STFX (P < 0.05). STFX showed the most potent activity against P. aeruginosa for recent pathogens recovered from CSOM as compared with the others, suggesting that the clinical application of topical STFX would be useful to prevent the emergence of resistant mutants of P. aeruginosa. |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 3 | 21% |
Other | 2 | 14% |
Student > Bachelor | 2 | 14% |
Student > Postgraduate | 2 | 14% |
Student > Master | 1 | 7% |
Other | 1 | 7% |
Unknown | 3 | 21% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 5 | 36% |
Biochemistry, Genetics and Molecular Biology | 3 | 21% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 14% |
Immunology and Microbiology | 1 | 7% |
Unknown | 3 | 21% |