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HtpG contributes to Salmonella Typhimurium intestinal persistence in pigs

Overview of attention for article published in Veterinary Research, October 2015
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Title
HtpG contributes to Salmonella Typhimurium intestinal persistence in pigs
Published in
Veterinary Research, October 2015
DOI 10.1186/s13567-015-0261-5
Pubmed ID
Authors

Elin Verbrugghe, Alexander Van Parys, Bregje Leyman, Filip Boyen, Freddy Haesebrouck, Frank Pasmans

Abstract

Salmonella enterica subspecies enterica serovar Typhimurium (Salmonella Typhimurium) contamination of pork, is one of the major sources of human salmonellosis. The bacterium is able to persist and hide in asymptomatic carrier animals, generating a reservoir for Salmonella transmission to other animals and humans. Mechanisms involved in Salmonella persistence in pigs remain poorly understood. In the present study, we demonstrate that the Salmonella htpG gene, encoding a homologue of the eukaryotic heat shock protein 90, contributes to Salmonella Typhimurium persistence in intestine-associated tissues of pigs, but not in the tonsils. HtpG does not seem to play an important role during the acute phase of infection. The contribution to persistence was shown to be associated with htpG-dependent Salmonella invasion and survival in porcine enterocytes and macrophages. These results reveal the role of HtpG as a virulence factor contributing to Salmonella persistence in pigs.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 22%
Student > Doctoral Student 3 13%
Student > Master 3 13%
Other 2 9%
Student > Ph. D. Student 2 9%
Other 3 13%
Unknown 5 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 8 35%
Veterinary Science and Veterinary Medicine 3 13%
Biochemistry, Genetics and Molecular Biology 3 13%
Chemistry 2 9%
Medicine and Dentistry 1 4%
Other 1 4%
Unknown 5 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 October 2015.
All research outputs
#20,657,128
of 25,374,917 outputs
Outputs from Veterinary Research
#1,035
of 1,337 outputs
Outputs of similar age
#213,236
of 291,144 outputs
Outputs of similar age from Veterinary Research
#34
of 44 outputs
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