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The effect of intracerebroventricular administration of orexin receptor type 2 antagonist on pentylenetetrazol-induced kindled seizures and anxiety in rats

Overview of attention for article published in BMC Neuroscience, August 2018
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Title
The effect of intracerebroventricular administration of orexin receptor type 2 antagonist on pentylenetetrazol-induced kindled seizures and anxiety in rats
Published in
BMC Neuroscience, August 2018
DOI 10.1186/s12868-018-0445-9
Pubmed ID
Authors

Saeedeh Asadi, Ali Roohbakhsh, Ali Shamsizadeh, Masoud Fereidoni, Elham Kordijaz, Ali Moghimi

Abstract

Current antiepileptic drugs are not able to prevent recurrent seizures in all patients. Orexins are excitatory hypothalamic neuropeptides that their receptors (Orx1R and Orx2R) are found almost in all major regions of the brain. Pentylenetetrazol (PTZ)-induced kindling is a known experimental model for epileptic seizures. The purpose of this study was to evaluate the effect of Orx2 receptor antagonist (TCS OX2 29) on seizures and anxiety of PTZ-kindled rats. Our results revealed that similar to valproate, administration of 7 µg/rat of TCS OX2 29 increased the latency period and decreased the duration time of 3rd and 4th stages of epileptiform seizures. Besides, it significantly decreased mean of seizure scores. However, TCS OX2 29 did not modulate anxiety induced by repeated PTZ administration. This study showed that blockade of Orx2 receptor reduced seizure-related behaviors without any significant effect on PTZ-induced anxiety.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 21%
Student > Bachelor 3 21%
Student > Master 3 21%
Student > Ph. D. Student 2 14%
Other 1 7%
Other 0 0%
Unknown 2 14%
Readers by discipline Count As %
Neuroscience 3 21%
Pharmacology, Toxicology and Pharmaceutical Science 3 21%
Business, Management and Accounting 1 7%
Biochemistry, Genetics and Molecular Biology 1 7%
Immunology and Microbiology 1 7%
Other 3 21%
Unknown 2 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 August 2018.
All research outputs
#10,210,736
of 13,385,815 outputs
Outputs from BMC Neuroscience
#671
of 1,035 outputs
Outputs of similar age
#184,172
of 266,734 outputs
Outputs of similar age from BMC Neuroscience
#1
of 1 outputs
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