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A rare coincidence of different types of driver mutations among uterine leiomyomas (UL)

Overview of attention for article published in Molecular Cytogenetics, October 2015
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Title
A rare coincidence of different types of driver mutations among uterine leiomyomas (UL)
Published in
Molecular Cytogenetics, October 2015
DOI 10.1186/s13039-015-0177-9
Pubmed ID
Authors

Carsten Holzmann, Dominique Nadine Markowski, Sabine Bartnitzke, Dirk Koczan, Burkhard Maria Helmke, Jörn Bullerdiek

Abstract

Mutations of mediator subcomplex 12 (MED12) and of high mobility group protein AT-hook 2 (HMGA2) are driver mutations in uterine leiomyomas (UL) that have not been observed to coexist in one tumor and even rarely coexist in different UL tumors of one patient. Here we describe a patient who underwent hysterectomy because of multiple leiomyomas which were studied by cytogenetics, MED12 hotspot sequencing, and copy number variation arrays. Two of the UL tumors had different HMGA2 rearrangements not detected by G-banding. Two UL tumors had deletions of the long arm of chromosome 3, in one case associated with a MED12 mutation. Both deletions lead to the loss of MED12L showing strong similarity with MED12. It remains to be determined if this gene can play a role in leiomyomagenesis independent of MED12. In summary, the patient presented exhibits an unusual coincidence of different driver mutations among her leiomyomas.

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Mendeley readers

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The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 7%
Unknown 13 93%

Demographic breakdown

Readers by professional status Count As %
Other 2 14%
Student > Master 2 14%
Professor > Associate Professor 2 14%
Researcher 2 14%
Student > Ph. D. Student 2 14%
Other 3 21%
Unknown 1 7%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 6 43%
Agricultural and Biological Sciences 2 14%
Medicine and Dentistry 2 14%
Nursing and Health Professions 1 7%
Computer Science 1 7%
Other 1 7%
Unknown 1 7%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 October 2015.
All research outputs
#17,286,934
of 25,383,278 outputs
Outputs from Molecular Cytogenetics
#164
of 422 outputs
Outputs of similar age
#172,026
of 287,429 outputs
Outputs of similar age from Molecular Cytogenetics
#7
of 11 outputs
Altmetric has tracked 25,383,278 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 422 research outputs from this source. They receive a mean Attention Score of 2.4. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
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