Title |
Dexamethasone and Salbutamol Stimulate Human Lung Fibroblast Proliferation
|
---|---|
Published in |
World Allergy Organization Journal, January 2011
|
DOI | 10.1097/wox.0b013e31821d1186 |
Pubmed ID | |
Authors |
Eran Pickholtz, Dan Admon, Uzi Izhar, Neville Berkman, Francesca Levi-Schaffer |
Abstract |
One obstacle to developing an effective therapeutic strategy to treat or prevent asthma is that the fundamental causes of asthma are not totally understood. Asthma is thought to be a chronic TH2 immune-mediated inflammatory disease. Epigenetic changes are recognized to play a role in the initiation and maintenance of a TH2 response. MicroRNAs (miRNAs) are key epigenetic regulators of gene expression, and their expression is highly regulated, therefore, deregulation of miRNAs may play an important role in the pathogenesis of asthma. Profiling circulating miRNA might provide the highest specificity and sensitivity to diagnose asthma; similarly, correcting potential defects in the miRNA regulation network may lead to new therapeutic modalities to treat this disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Argentina | 1 | 13% |
Unknown | 7 | 88% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 7 | 88% |
Scientists | 1 | 13% |