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Increased interleukin-10 and interferon-γ levels in Plasmodium vivax malaria suggest a reciprocal regulation which is not altered by IL-10 gene promoter polymorphism

Overview of attention for article published in Malaria Journal, September 2011
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (73rd percentile)
  • Good Attention Score compared to outputs of the same age and source (76th percentile)

Mentioned by

blogs
1 blog

Citations

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60 Dimensions

Readers on

mendeley
106 Mendeley
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Title
Increased interleukin-10 and interferon-γ levels in Plasmodium vivax malaria suggest a reciprocal regulation which is not altered by IL-10 gene promoter polymorphism
Published in
Malaria Journal, September 2011
DOI 10.1186/1475-2875-10-264
Pubmed ID
Authors

Tiago S Medina, Sheyla PT Costa, Maria D Oliveira, Ana M Ventura, José M Souza, Tassia F Gomes, Antonio CR Vallinoto, Marinete M Póvoa, João S Silva, Maristela G Cunha

Abstract

In human malaria, the naturally-acquired immune response can result in either the elimination of the parasite or a persistent response mediated by cytokines that leads to immunopathology. The cytokines are responsible for all the symptoms, pathological alterations and the outcome of the infection depends on the reciprocal regulation of the pro and anti-inflammatory cytokines. IL-10 and IFN-gamma are able to mediate this process and their production can be affected by single nucleotide polymorphisms (SNPs) on gene of these cytokines. In this study, the relationship between cytokine IL-10/IFN-gamma levels, parasitaemia, and their gene polymorphisms was examined and the participation of pro-inflammatory and regulatory balance during a natural immune response in Plasmodium vivax-infected individuals was observed.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 2%
Spain 1 <1%
Pakistan 1 <1%
India 1 <1%
Unknown 101 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 22 21%
Student > Master 16 15%
Student > Bachelor 13 12%
Researcher 11 10%
Student > Postgraduate 8 8%
Other 16 15%
Unknown 20 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 38 36%
Medicine and Dentistry 17 16%
Biochemistry, Genetics and Molecular Biology 13 12%
Immunology and Microbiology 9 8%
Chemistry 3 3%
Other 8 8%
Unknown 18 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2011.
All research outputs
#5,703,409
of 22,659,164 outputs
Outputs from Malaria Journal
#1,507
of 5,535 outputs
Outputs of similar age
#33,100
of 126,338 outputs
Outputs of similar age from Malaria Journal
#14
of 59 outputs
Altmetric has tracked 22,659,164 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 5,535 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 126,338 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.