Title |
Increased interleukin-10 and interferon-γ levels in Plasmodium vivax malaria suggest a reciprocal regulation which is not altered by IL-10 gene promoter polymorphism
|
---|---|
Published in |
Malaria Journal, September 2011
|
DOI | 10.1186/1475-2875-10-264 |
Pubmed ID | |
Authors |
Tiago S Medina, Sheyla PT Costa, Maria D Oliveira, Ana M Ventura, José M Souza, Tassia F Gomes, Antonio CR Vallinoto, Marinete M Póvoa, João S Silva, Maristela G Cunha |
Abstract |
In human malaria, the naturally-acquired immune response can result in either the elimination of the parasite or a persistent response mediated by cytokines that leads to immunopathology. The cytokines are responsible for all the symptoms, pathological alterations and the outcome of the infection depends on the reciprocal regulation of the pro and anti-inflammatory cytokines. IL-10 and IFN-gamma are able to mediate this process and their production can be affected by single nucleotide polymorphisms (SNPs) on gene of these cytokines. In this study, the relationship between cytokine IL-10/IFN-gamma levels, parasitaemia, and their gene polymorphisms was examined and the participation of pro-inflammatory and regulatory balance during a natural immune response in Plasmodium vivax-infected individuals was observed. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 2 | 2% |
Spain | 1 | <1% |
Pakistan | 1 | <1% |
India | 1 | <1% |
Unknown | 101 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 22 | 21% |
Student > Master | 16 | 15% |
Student > Bachelor | 13 | 12% |
Researcher | 11 | 10% |
Student > Postgraduate | 8 | 8% |
Other | 16 | 15% |
Unknown | 20 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 38 | 36% |
Medicine and Dentistry | 17 | 16% |
Biochemistry, Genetics and Molecular Biology | 13 | 12% |
Immunology and Microbiology | 9 | 8% |
Chemistry | 3 | 3% |
Other | 8 | 8% |
Unknown | 18 | 17% |