Title |
Antiangiogenic properties of Koetjapic acid, a natural triterpene isolated from Sandoricum koetjaoe Merr
|
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Published in |
Cancer Cell International, April 2011
|
DOI | 10.1186/1475-2867-11-12 |
Pubmed ID | |
Authors |
Zeyad D Nassar, Abdalrahim FA Aisha, Mohamed BK Ahamed, Zhari Ismail, Khalid M Abu-Salah, Salman A Alrokayan, Amin Malik Shah Abdul Majid |
Abstract |
Angiogenesis, the formation of new blood vessels, has become an important target in cancer therapy. Angiogenesis plays an important role in tumor growth and metastasis. Koetjapic acid (KA) is a seco-A-ring oleanene triterpene isolated from S. koetjape. The solvent extract of this plant species was shown previously to have strong antiangiogenic activity; however the active ingredient(s) that conferred the biological activity and the mode of action was not established. Given the high concentration of KA in S. koetjape, an attempt has been made in this study to investigate the antiangiogenic properties of KA. |
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