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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Promoter-like epigenetic signatures in exons displaying cell type-specific splicing
|
|---|---|
| Published in |
Genome Biology, October 2015
|
| DOI | 10.1186/s13059-015-0797-8 |
| Pubmed ID | |
| Authors |
Joao Curado, Camilla Iannone, Hagen Tilgner, Juan Valcárcel, Roderic Guigó |
| Abstract |
Pre-mRNA splicing occurs mainly co-transcriptionally, and both nucleosome density and histone modifications have been proposed to play a role in splice site recognition and regulation. However, the extent and mechanisms behind this interplay remain poorly understood. We use transcriptomic and epigenomic data generated by the ENCODE project to investigate the association between chromatin structure and alternative splicing. We find a strong and significant positive association between H3K9ac, H3K27ac, H3K4me3, epigenetic marks characteristic of active promoters, and exon inclusion in a small but well-defined class of exons, representing approximately 4 % of all regulated exons. These exons are systematically maintained at comparatively low levels of inclusion across cell types, but their inclusion is significantly enhanced in particular cell types when in physical proximity to active promoters. Histone modifications and other chromatin features that activate transcription can be co-opted to participate in the regulation of the splicing of exons that are in physical proximity to promoter regions. |
X Demographics
The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 24% |
| United Kingdom | 3 | 14% |
| France | 1 | 5% |
| Puerto Rico | 1 | 5% |
| Australia | 1 | 5% |
| Unknown | 10 | 48% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 57% |
| Scientists | 8 | 38% |
| Science communicators (journalists, bloggers, editors) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 2% |
| Netherlands | 1 | <1% |
| Germany | 1 | <1% |
| Ukraine | 1 | <1% |
| Spain | 1 | <1% |
| Greece | 1 | <1% |
| United States | 1 | <1% |
| Luxembourg | 1 | <1% |
| Unknown | 118 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 42 | 33% |
| Researcher | 31 | 24% |
| Student > Master | 11 | 9% |
| Student > Doctoral Student | 8 | 6% |
| Student > Bachelor | 6 | 5% |
| Other | 15 | 12% |
| Unknown | 14 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 53 | 42% |
| Biochemistry, Genetics and Molecular Biology | 43 | 34% |
| Computer Science | 9 | 7% |
| Mathematics | 1 | <1% |
| Immunology and Microbiology | 1 | <1% |
| Other | 3 | 2% |
| Unknown | 17 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 April 2016.
All research outputs
#3,240,483
of 25,373,627 outputs
Outputs from Genome Biology
#2,346
of 4,467 outputs
Outputs of similar age
#43,586
of 294,824 outputs
Outputs of similar age from Genome Biology
#49
of 86 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,467 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 27.6. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 294,824 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 86 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.