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Survival in sinonasal and middle ear malignancies: a population-based study using the SEER 1973–2015 database

Overview of attention for article published in BMC Ear, Nose and Throat Disorders, August 2018
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Title
Survival in sinonasal and middle ear malignancies: a population-based study using the SEER 1973–2015 database
Published in
BMC Ear, Nose and Throat Disorders, August 2018
DOI 10.1186/s12901-018-0061-4
Pubmed ID
Authors

Mitchell R. Gore

Abstract

The sinuses, nasal cavity, and middle ear represent a rarer location of head and neck malignancy than more common sites such as the larynx and oral cavity. Population-based studies are a useful tool to study the demographic and treatment factors affecting survival in these malignancies. Population-based database search of the Survival, Epidemiology, and End Results (SEER) database from 1973 to 2015 for malignancies involving the nasal cavity, paranasal sinuses, and middle ear. Data were analyzed for demographics, treatment type, stage, primary site and histopathologic type. Kaplan-Meier analysis was used to assess and compare survival. A total of 13,992 cases of sinonasal or middle ear malignancy were identified and analyzed. The majority of patients were between ages 50 and 80 at the time of diagnosis. Overall 5-, 10-, and 20-year survival was 45.7%, 32.2%, and 16.4%, respectively. Lymph node metastasis was reported in 4.4% of patients, while distant metastasis was present in 1.5% of cases. On univariate analysis surgical vs. nonsurgical treatment, sex, race, age at diagnosis, T stage, N stage, M stage, AJCC overall stage, primary site, tumor grade, and histopathologic subtype significantly affected survival. On multivariate analysis age, race, sex, primary site, overall AJCC stage, surgical vs. nonsurgical treatment, and T, N, and M stage remained significant predictors of overall survival. Malignancies of the nasal cavity, paranasal sinuses, and middle ear account for a minority of overall head and neck cancers. The overall 5-, 10-, and 20-year survival for these malignancies is relatively low. Higher T, N, M, and overall stage and higher tumor grade is associated with lower survival. Patients treated with surgery as part of the treatment regimen had higher overall survival. Demographics and primary site also significantly affect survival. Certain histopathologic subtypes were associated with poorer survival.

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Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Librarian 3 13%
Student > Bachelor 3 13%
Student > Master 3 13%
Other 2 9%
Student > Postgraduate 2 9%
Other 3 13%
Unknown 7 30%
Readers by discipline Count As %
Medicine and Dentistry 10 43%
Arts and Humanities 2 9%
Agricultural and Biological Sciences 1 4%
Immunology and Microbiology 1 4%
Neuroscience 1 4%
Other 0 0%
Unknown 8 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 August 2018.
All research outputs
#20,530,891
of 23,100,534 outputs
Outputs from BMC Ear, Nose and Throat Disorders
#66
of 83 outputs
Outputs of similar age
#289,155
of 331,391 outputs
Outputs of similar age from BMC Ear, Nose and Throat Disorders
#4
of 5 outputs
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