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The clinical prognostic significance of hs-cTnT elevation in patients with acute ischemic stroke

Overview of attention for article published in BMC Neurology, August 2018
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Title
The clinical prognostic significance of hs-cTnT elevation in patients with acute ischemic stroke
Published in
BMC Neurology, August 2018
DOI 10.1186/s12883-018-1121-5
Pubmed ID
Authors

Lanying He, Jian Wang, Weiwei Dong

Abstract

Cardiac autonomic dysfunction caused by ischemic stroke might lead to an adverse outcome. Elevated high sensitivity cardiac troponin (hs-cTnT) is a marker of cardiac disease, it can elevate in acute stroke patients. The aim of the present study was to investigate association between serum hs-cTnT with prognosis among patients with acute ischemic stroke. Five hundred and sixteen patients (mean age 66.19 ± 10.11) with acute ischemic stroke underwent a comprehensive clinical investigation and serum hs-cTnT activity test. All patients were followed up for 3 months. The prognosis was death or major disability (modified Rankin Scale score ≥ 3) at 3 months after acute ischemic stroke. 22.87% (118/516) of patients had serum hs-cTnT elevation (≥14 ng/l). Compared with normal hs-TnT group, the incidence of insular stroke (adjusted odds ratio, 2.84; 95% confidence interval, 1.48-4.17; P = 0.001) were more likely in patients with hs-cTnT elevation. In fully adjusted models, there was an association between serum hs-cTnT elevation and death (adjusted odds ratio, 3.14; 95% confidence interval, 1.16-8.49; P = 0.02) and major disability(adjusted odds ratio, 2.07; 95% confidence interval, 1.04-4.51; P = 0.04), and composite outcome(adjusted odds ratio,2.22;95% confidence interval,1.10-4.48; P = 0.03). Higher levels of serum hs-cTnT were independently associated with increased risk of death or major disability after stroke onset, suggesting that serum hs-cTnT may have prognostic value in poor outcomes of ischemic stroke.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 18%
Other 3 11%
Student > Postgraduate 3 11%
Student > Master 3 11%
Student > Bachelor 2 7%
Other 2 7%
Unknown 10 36%
Readers by discipline Count As %
Medicine and Dentistry 11 39%
Nursing and Health Professions 4 14%
Agricultural and Biological Sciences 1 4%
Immunology and Microbiology 1 4%
Neuroscience 1 4%
Other 0 0%
Unknown 10 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 August 2018.
All research outputs
#20,530,891
of 23,100,534 outputs
Outputs from BMC Neurology
#2,166
of 2,469 outputs
Outputs of similar age
#290,758
of 333,688 outputs
Outputs of similar age from BMC Neurology
#29
of 42 outputs
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