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Hepatitis D virus and hepatitis B virus infection in Amerindian communities of the Amazonas state, Colombia

Overview of attention for article published in Virology Journal, October 2015
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Title
Hepatitis D virus and hepatitis B virus infection in Amerindian communities of the Amazonas state, Colombia
Published in
Virology Journal, October 2015
DOI 10.1186/s12985-015-0402-5
Pubmed ID
Authors

Diana di Filippo Villa, Fabian Cortes-Mancera, Edra Payares, Neyla Montes, Fernando de la Hoz, Maria Patricia Arbelaez, Gonzalo Correa, Maria-Cristina Navas

Abstract

In Colombia, cases of Hepatitis D virus (HDV) infection have been officially described since 1985 mainly in Amerindian population from Sierra Nevada de Santa Marta (North Caribbean Coast), Uraba (North West), and Amazon (South East). The last official report of a clinical case of HDV infection in Colombia was registered in 2005. The aims of this study were to identify cases of HDV and/or Hepatitis B virus (HBV) infection in asymptomatic Amerindians from Amazonas state, South East Colombia, and to describe the circulating viral genotypes in this population. The study population was recruited in 19 Amerindian communities in the Amazonas state. Individuals over 18 years old were screened by rapid test for Hepatitis B surface Antigen (HBsAg). Blood samples obtained from individuals positives for HBsAg in the rapid-test assay were analyzed for HBsAg, anti-HBc, anti-HDV IgM/IgG by ELISA. The detection of HBV DNA and HDV RNA was performed by PCR amplification. The viral genotype was determined by sequencing and phylogenetic analysis. A total of 23/861 individuals were positive for HBsAg detection by rapid test. Serological and/or molecular markers of HDV infection were demonstrated in 43.5 % (10/23) of samples from Amerindians. The phylogenetic analysis demonstrated the exclusive circulation of HBV subgenotype F1b of and HDV 3 in this population. A high frequency of HBV/HDV infection was found in Amerindian population from Amazonas State, Colombia (43.5 %, 10/23). Nine cases were identified in a population of 861 asymptomatic Amerindian individuals; one symptomatic case (with diagnosis of end-stage hepatic disease) was also identified in the study. The circulation of HDV 3 and HBV subgenotype F1b suggests a constant flow of these viral genotypes as a result of the interaction of the Amerindian populations from Amazon basin. Further studies are necessary to confirm whether HBV subgenotype F1b is the prevalent in the population from South East region in Colombia.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 71 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 13%
Student > Postgraduate 9 13%
Student > Master 9 13%
Student > Bachelor 9 13%
Student > Ph. D. Student 5 7%
Other 13 18%
Unknown 17 24%
Readers by discipline Count As %
Medicine and Dentistry 13 18%
Biochemistry, Genetics and Molecular Biology 13 18%
Agricultural and Biological Sciences 7 10%
Immunology and Microbiology 6 8%
Social Sciences 3 4%
Other 8 11%
Unknown 21 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 November 2015.
All research outputs
#13,449,870
of 22,831,537 outputs
Outputs from Virology Journal
#1,362
of 3,043 outputs
Outputs of similar age
#134,535
of 283,725 outputs
Outputs of similar age from Virology Journal
#24
of 63 outputs
Altmetric has tracked 22,831,537 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,043 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.8. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 283,725 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.