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Hepatitis C in the era of direct-acting antivirals: real-world costs of untreated chronic hepatitis C; a cross-sectional study

Overview of attention for article published in BMC Infectious Diseases, October 2015
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Title
Hepatitis C in the era of direct-acting antivirals: real-world costs of untreated chronic hepatitis C; a cross-sectional study
Published in
BMC Infectious Diseases, October 2015
DOI 10.1186/s12879-015-1208-1
Pubmed ID
Authors

Jennifer Ann Kieran, Suzanne Norris, Aisling O’Leary, Cathal Walsh, Raphael Merriman, D. Houlihan, P. Aiden McCormick, Susan McKiernan, Colm Bergin, Michael Barry

Abstract

Recent advances in Hepatitis C therapeutics offer the possibility of cure but will be expensive. The cost of treatment may be partially offset by the avoidance of advanced liver disease. We performed a micro-costing study of the ambulatory healthcare utilisation of patients with Hepatitis C supplemented with inpatient diagnosis related group costs. The staff utilisation costs associated with a Hepatitis C ambulatory visit were measured and combined with the costs of investigations to establish a mean cost per consultation. An annualised estimate of cost was produced by multiplying this by the number of consultations accessed, stratified by degree of liver impairment. Inpatient costs were established by identifying the number of inpatient episodes and multiplying by Irish diagnosis related group costs. Non-parametric bootstrapping was performed to derive mean and 95%CI values. Two hundred and twenty-five patients were identified. The cost of an outpatient medical review was €136 (€3.60 SD). The cost of a Hepatitis C nursing review was €128 (€7.30 SD). The annual mean costs of care were as follows (95%CI): Mild €398 (€336, €482), Moderate €417(€335, €503), Compensated cirrhosis €1790 (€990, €3164), Decompensated cirrhosis €8302 (€3945, €14,637), Transplantation Year 1 €137,176 (€136,024, €138,306), Transplantation after Year 1 €5337 (€4942, €5799), Hepatocellular carcinoma €21,992 (€15,222, €29,467), Sustained virological response €44 (€16, €73). The direct medical cost associated with Hepatitis C care in Ireland is substantial and increases exponentially with progression of liver disease. The follow-up costs of patients with a sustained virological response in this cohort were low in comparison to patients with chronic infection.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 56 98%

Demographic breakdown

Readers by professional status Count As %
Other 10 18%
Student > Master 8 14%
Researcher 7 12%
Student > Postgraduate 5 9%
Student > Ph. D. Student 4 7%
Other 14 25%
Unknown 9 16%
Readers by discipline Count As %
Medicine and Dentistry 21 37%
Nursing and Health Professions 6 11%
Economics, Econometrics and Finance 4 7%
Mathematics 3 5%
Agricultural and Biological Sciences 3 5%
Other 7 12%
Unknown 13 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 May 2016.
All research outputs
#22,303,808
of 24,892,887 outputs
Outputs from BMC Infectious Diseases
#7,102
of 8,373 outputs
Outputs of similar age
#248,254
of 290,629 outputs
Outputs of similar age from BMC Infectious Diseases
#155
of 166 outputs
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