Title |
PD-L1 in pancreatic ductal adenocarcinoma: a retrospective analysis of 373 Chinese patients using an in vitro diagnostic assay
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Published in |
Diagnostic Pathology, January 2018
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DOI | 10.1186/s13000-017-0678-4 |
Pubmed ID | |
Authors |
Xiaolong Liang, Jian Sun, Huanwen Wu, Yufeng Luo, Lili Wang, Junliang Lu, Zhiwen Zhang, Junchao Guo, Zhiyong Liang, Tonghua Liu |
Abstract |
Programmed death ligand 1 (PD-L1) has shown potential as a therapeutic target in numerous solid tumors. Its prognostic significance has also been established in pancreatic ductal adenocarcinoma (PDAC). The present study aimed to explore PD-L1 expression in PDAC cases in a large Chinese cohort using an in vitro diagnostic (IVD) assay to provide further insight into the potential value of programmed cell death protein 1 (PD-1) as a therapeutic target. Three hundred seventy-three PDAC patients were retrospectively recruited in this study. Tissue microarray (TMA) blocks were made from available formalin-fixed and paraffin-embedded (FFPE) tumor and matched adjacent tissue specimens. We evaluated PD-L1 protein expression via immunohistochemistry (IHC) using a U.S. Food and Drug Administration (FDA)-approved IVD assay. The relationships between PD-L1 positivity and both clinicopathological characteristics and patient prognosis were analyzed. PD-1 expression and clinicopathological significance were also evaluated. PD-L1 and PD-1 positivity were observed in 3.2% and 7.5% of cases, respectively. PD-L1 showed a predominantly membranous pattern in tumor cells, while no positive PD-L1 staining was observed in normal regions. Statistical analyses revealed that PD-L1 expression was associated with lymph node metastasis. PD-L1 positivity was a prognostic indicator of progression-free survival (PFS) and overall survival (OS) in univariate analyses, but only PFS remained statistically significant in multivariate analysis. PD-1 expression was detected in lymphocytes and was not associated with any clinicopathological feature except a history of pancreatitis. The PD-L1 positivity rate is low in PDAC when evaluated using a companion diagnostic assay. It remains an independent prognostic factor for poor PFS. |
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United States | 1 | 50% |
Comoros | 1 | 50% |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 24 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Postgraduate | 4 | 17% |
Student > Master | 3 | 13% |
Student > Bachelor | 2 | 8% |
Other | 2 | 8% |
Researcher | 2 | 8% |
Other | 5 | 21% |
Unknown | 6 | 25% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 9 | 38% |
Biochemistry, Genetics and Molecular Biology | 4 | 17% |
Psychology | 2 | 8% |
Nursing and Health Professions | 1 | 4% |
Unspecified | 1 | 4% |
Other | 1 | 4% |
Unknown | 6 | 25% |