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Co-culture of Retinal and Endothelial Cells Results in the Modulation of Genes Critical to Retinal Neovascularization

Overview of attention for article published in Vascular Cell, November 2011
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  • Good Attention Score compared to outputs of the same age (70th percentile)

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1 X user
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2 patents

Citations

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111 Mendeley
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Title
Co-culture of Retinal and Endothelial Cells Results in the Modulation of Genes Critical to Retinal Neovascularization
Published in
Vascular Cell, November 2011
DOI 10.1186/2045-824x-3-27
Pubmed ID
Authors

Ravindra Kumar, Sandra Harris-Hooker, Ritesh Kumar, Gary Sanford

Abstract

Neovascularization (angiogenesis) is a multistep process, controlled by opposing regulatory factors, which plays a crucial role in several ocular diseases. It often results in vitreous hemorrhage, retinal detachment, neovascularization glaucoma and subsequent vision loss. Hypoxia is considered to be one of the key factors to trigger angiogenesis by inducing angiogenic factors (like VEGF) and their receptors mediated by hypoxia inducible factor-1 (HIF-1α) a critical transcriptional factor. Another factor, nuclear factor kappa B (NFκB) also regulates many of the genes required for neovascularization, and can also be activated by hypoxia. The aim of this study was to elucidate the mechanism of interaction between HRPC and HUVEC that modulates a neovascularization response.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 111 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 111 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 22%
Student > Bachelor 19 17%
Researcher 15 14%
Student > Master 15 14%
Student > Postgraduate 6 5%
Other 12 11%
Unknown 20 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 25 23%
Biochemistry, Genetics and Molecular Biology 24 22%
Medicine and Dentistry 16 14%
Engineering 8 7%
Neuroscience 4 4%
Other 10 9%
Unknown 24 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 December 2021.
All research outputs
#8,270,860
of 25,394,764 outputs
Outputs from Vascular Cell
#33
of 72 outputs
Outputs of similar age
#69,275
of 245,376 outputs
Outputs of similar age from Vascular Cell
#2
of 4 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 72 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 245,376 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.