Title |
Co-culture of Retinal and Endothelial Cells Results in the Modulation of Genes Critical to Retinal Neovascularization
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Published in |
Vascular Cell, November 2011
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DOI | 10.1186/2045-824x-3-27 |
Pubmed ID | |
Authors |
Ravindra Kumar, Sandra Harris-Hooker, Ritesh Kumar, Gary Sanford |
Abstract |
Neovascularization (angiogenesis) is a multistep process, controlled by opposing regulatory factors, which plays a crucial role in several ocular diseases. It often results in vitreous hemorrhage, retinal detachment, neovascularization glaucoma and subsequent vision loss. Hypoxia is considered to be one of the key factors to trigger angiogenesis by inducing angiogenic factors (like VEGF) and their receptors mediated by hypoxia inducible factor-1 (HIF-1α) a critical transcriptional factor. Another factor, nuclear factor kappa B (NFκB) also regulates many of the genes required for neovascularization, and can also be activated by hypoxia. The aim of this study was to elucidate the mechanism of interaction between HRPC and HUVEC that modulates a neovascularization response. |
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Unknown | 1 | 100% |
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Members of the public | 1 | 100% |
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Student > Ph. D. Student | 24 | 22% |
Student > Bachelor | 19 | 17% |
Researcher | 15 | 14% |
Student > Master | 15 | 14% |
Student > Postgraduate | 6 | 5% |
Other | 12 | 11% |
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Neuroscience | 4 | 4% |
Other | 10 | 9% |
Unknown | 24 | 22% |