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The etiology of idiopathic congenital talipes equinovarus: a systematic review

Overview of attention for article published in Journal of Orthopaedic Surgery and Research, August 2018
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (76th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

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Title
The etiology of idiopathic congenital talipes equinovarus: a systematic review
Published in
Journal of Orthopaedic Surgery and Research, August 2018
DOI 10.1186/s13018-018-0913-z
Pubmed ID
Authors

Vito Pavone, Emanuele Chisari, Andrea Vescio, Ludovico Lucenti, Giuseppe Sessa, Gianluca Testa

Abstract

Also known as clubfoot, idiopathic congenital talipes equinovarus (ICTEV) is the most common pediatric deformity and occurs in 1 in every 1000 live births. Even though it has been widely researched, the etiology of ICTEV remains poorly understood and is often described as being based on a multifactorial genesis. Genetic and environmental factors seem to have a major role in the development of this disease. Thus, the aim of this review is to analyze the available literature to document the current evidence on ICTEV etiology. The literature on ICTEV etiology was systematically reviewed using the following inclusion criteria: studies of any level of evidence, reporting clinical or preclinical results, published in the last 20 years (1998-2018), and dealing with the etiology of ICTEV. A total of 48 articles were included. ICTEV etiology is still controversial. Several hypotheses have been researched, but none of them are decisive. Emerging evidence suggests a role of several pathways and gene families associated with limb development (HOX family; PITX1-TBX4), the apoptotic pathway (caspases), and muscle contractile protein (troponin and tropomyosin), but a major candidate gene has still not been identified. Strong recent evidence emerging from twin studies confirmed major roles of genetics and the environment in the disease pathogenesis. The available literature on the etiology of ICTEV presents major limitations in terms of great heterogeneity and a lack of high-profile studies. Although many studies focus on the genetic background of the disease, there is lack of consensus on one or multiple targets. Genetics and smoking seem to be strongly associated with ICTEV etiology, but more studies are needed to understand the complex and multifactorial genesis of this common congenital lower-limb disease.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 236 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 236 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 37 16%
Student > Postgraduate 20 8%
Researcher 17 7%
Other 13 6%
Student > Master 12 5%
Other 29 12%
Unknown 108 46%
Readers by discipline Count As %
Medicine and Dentistry 76 32%
Nursing and Health Professions 20 8%
Biochemistry, Genetics and Molecular Biology 9 4%
Sports and Recreations 4 2%
Chemistry 2 <1%
Other 13 6%
Unknown 112 47%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 September 2023.
All research outputs
#4,371,080
of 24,364,603 outputs
Outputs from Journal of Orthopaedic Surgery and Research
#137
of 1,516 outputs
Outputs of similar age
#80,190
of 337,614 outputs
Outputs of similar age from Journal of Orthopaedic Surgery and Research
#2
of 28 outputs
Altmetric has tracked 24,364,603 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,516 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 337,614 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.