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Do cognitive measures and brain circuitry predict outcomes of exercise in Parkinson Disease: a randomized clinical trial

Overview of attention for article published in BMC Neurology, October 2015
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Title
Do cognitive measures and brain circuitry predict outcomes of exercise in Parkinson Disease: a randomized clinical trial
Published in
BMC Neurology, October 2015
DOI 10.1186/s12883-015-0474-2
Pubmed ID
Authors

LA King, DS Peterson, M. Mancini, P. Carlson-Kuhta, BW Fling, K. Smulders, JG Nutt, M. Dale, J. Carter, KM Winters-Stone, FB Horak

Abstract

There is emerging research detailing the relationship between balance/gait/falls and cognition. Imaging studies also suggest a link between structural and functional changes in the frontal lobe (a region commonly associated with cognitive function) and mobility. People with Parkinson's disease have important changes in cognitive function that may impact rehabilitation efficacy. Our underlying hypothesis is that cognitive function and frontal lobe connections with the basal ganglia and brainstem posture/locomotor centers are responsible for postural deficits in people with Parkinson's disease and play a role in rehabilitation efficacy. The purpose of this study is to 1) determine if people with Parkinson's disease can improve mobility and/or cognition after partaking in a cognitively challenging mobility exercise program and 2) determine if cognition and brain circuitry deficits predict responsiveness to exercise rehabilitation. This study is a randomized cross-over controlled intervention to take place at a University Balance Disorders Laboratory. The study participants will be people with Parkinson's disease who meet inclusion criteria for the study. The intervention will be 6 weeks of group exercise (case) and 6 weeks of group education (control). The exercise is a cognitively challenging program based on the Agility Boot Camp for people with PD. The education program is a 6-week program to teach people how to better live with a chronic disease. The primary outcome measure is the MiniBESTest and the secondary outcomes are measures of mobility, cognition and neural imaging. The results from this study will further our understanding of the relationship between cognition and mobility with a focus on brain circuitry as it relates to rehabilitation potential. This trial is registered at clinical trials.gov ( NCT02231073 ).

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 300 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Unknown 299 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 39 13%
Student > Master 33 11%
Student > Ph. D. Student 29 10%
Researcher 27 9%
Other 18 6%
Other 60 20%
Unknown 94 31%
Readers by discipline Count As %
Nursing and Health Professions 44 15%
Medicine and Dentistry 38 13%
Neuroscience 26 9%
Psychology 21 7%
Sports and Recreations 19 6%
Other 38 13%
Unknown 114 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 November 2015.
All research outputs
#18,429,829
of 22,831,537 outputs
Outputs from BMC Neurology
#1,889
of 2,435 outputs
Outputs of similar age
#204,229
of 283,719 outputs
Outputs of similar age from BMC Neurology
#54
of 66 outputs
Altmetric has tracked 22,831,537 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,435 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.