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Effect of surgical liver resection on circulating tumor cells in patients with hepatocellular carcinoma

Overview of attention for article published in BMC Cancer, August 2018
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Title
Effect of surgical liver resection on circulating tumor cells in patients with hepatocellular carcinoma
Published in
BMC Cancer, August 2018
DOI 10.1186/s12885-018-4744-4
Pubmed ID
Authors

Jing-jing Yu, Wei Xiao, Shui-lin Dong, Hui-fang Liang, Zhi-wei Zhang, Bi-xiang Zhang, Zhi-yong Huang, Yi-fa Chen, Wan-guang Zhang, Hong-ping Luo, Qian Chen, Xiao-ping Chen

Abstract

This study explored the effect of liver resection on perioperative circulating tumor cells (CTCs) and found that the prognostic significance of surgery was associated with changes in CTC counts in patients with hepatocellular carcinoma (HCC). One hundred thirty-nine patients with HCC were consecutively enrolled. The time-points for collecting blood were one day before operation and three days after operation. CTCs in the peripheral blood were detected by the CellSearch™ System. Both CTC detection incidence and mean CTC counts showed greater increases postoperatively (54%, mean 1.54 cells) than preoperatively (43%, mean 1.13 cells). The postoperative CTC counts increased in 41.7% of patients, decreased in 25.2% of patients and did not change in 33.1% of patients. The increase in postoperative CTC counts was significantly associated with the macroscopic tumor thrombus status. Patients with increased postoperative CTC counts (from preoperative CTC < 2 to postoperative CTC ≥ 2) had significantly shorter disease-free survival (DFS) and overall survival (OS) than did patients with persistent CTC < 2. Patients with persistent CTC levels of ≥2 had the worst prognoses. Surgical liver resection is associated with an increase in CTC counts, and increased postoperative CTC numbers are associated with a worse prognosis in patients with HCC.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 35 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 17%
Student > Master 6 17%
Student > Ph. D. Student 5 14%
Student > Bachelor 3 9%
Student > Postgraduate 3 9%
Other 5 14%
Unknown 7 20%
Readers by discipline Count As %
Medicine and Dentistry 10 29%
Biochemistry, Genetics and Molecular Biology 5 14%
Chemistry 2 6%
Nursing and Health Professions 1 3%
Agricultural and Biological Sciences 1 3%
Other 4 11%
Unknown 12 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 August 2018.
All research outputs
#20,530,891
of 23,100,534 outputs
Outputs from BMC Cancer
#6,550
of 8,386 outputs
Outputs of similar age
#290,758
of 333,688 outputs
Outputs of similar age from BMC Cancer
#109
of 145 outputs
Altmetric has tracked 23,100,534 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,386 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 333,688 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 145 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.