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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Modulation Effect of Longitudinal Acupuncture on Resting State Functional Connectivity in Knee Osteoarthritis Patients
|
|---|---|
| Published in |
Molecular Pain, October 2015
|
| DOI | 10.1186/s12990-015-0071-9 |
| Pubmed ID | |
| Authors |
Xiaoyan Chen, Rosa B. Spaeth, Sonya G. Freeman, Donna Moxley Scarborough, Javeria A. Hashmi, Hsiao-Ying Wey, Natalia Egorova, Mark Vangel, Jianren Mao, Ajay D. Wasan, Robert R. Edwards, Randy L. Gollub, Jian Kong |
| Abstract |
Recent advances in brain imaging have contributed to our understanding of the neural activity associated with acupuncture treatment. In this study, we investigated functional connectivity across longitudinal acupuncture treatments in older patients with knee osteoarthritis (OA). Over a period of 4 weeks (six treatments), we collected resting state functional magnetic resonance imaging (fMRI) scans from 30 patients before and after their first, third and sixth treatments. Clinical outcome showed a significantly greater pain subscore on the Knee Injury and Osteoarthritis Outcome Score (KOOS) (indicative of improvement) with verum acupuncture than with sham acupuncture. Independent component analysis (ICA) of the resting state fMRI data showed that the right frontoparietal network (rFPN) and the executive control network (ECN) showed enhanced functional connectivity (FC) with the rostral anterior cingulate cortex/medial prefrontal cortex, a key region in the descending pain modulatory system, in the verum groups as compared to the sham group after treatments. We also found that the rFPN connectivity with the left insula is (1) significantly associated with changes in KOOS pain score after treatments, and (2) significantly enhanced after verum acupuncture treatments as compared to sham treatment. Analysis of the acupuncture needle stimulation scan showed that compared with sham treatment, verum acupuncture activated the left operculum/insula, which also overlaps with findings observed in resting state analysis. Our results suggest that acupuncture may achieve its therapeutic effect on knee OA pain by modulating functional connectivity between the rFPN, ECN and the descending pain modulatory pathway. NCT01079390. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 25% |
| Spain | 1 | 25% |
| United Kingdom | 1 | 25% |
| Canada | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 25% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 196 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| Belgium | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 193 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 29 | 15% |
| Student > Bachelor | 27 | 14% |
| Researcher | 18 | 9% |
| Student > Ph. D. Student | 16 | 8% |
| Student > Postgraduate | 13 | 7% |
| Other | 31 | 16% |
| Unknown | 62 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 54 | 28% |
| Nursing and Health Professions | 30 | 15% |
| Neuroscience | 12 | 6% |
| Psychology | 10 | 5% |
| Agricultural and Biological Sciences | 4 | 2% |
| Other | 16 | 8% |
| Unknown | 70 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 November 2021.
All research outputs
#2,485,776
of 25,374,917 outputs
Outputs from Molecular Pain
#35
of 669 outputs
Outputs of similar age
#34,471
of 295,445 outputs
Outputs of similar age from Molecular Pain
#1
of 9 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 669 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 295,445 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them