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Fish oil-based lipid emulsion in the treatment of parenteral nutrition-associated cholestasis

Overview of attention for article published in Italian Journal of Pediatrics, August 2018
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Title
Fish oil-based lipid emulsion in the treatment of parenteral nutrition-associated cholestasis
Published in
Italian Journal of Pediatrics, August 2018
DOI 10.1186/s13052-018-0539-0
Pubmed ID
Authors

Simonetta Costa, Rossella Iannotta, Luca Maggio, Giovanni Barone, Francesca Serrao, Giovanni Vento

Abstract

Parenteral nutrition-associated cholestasis (PNAC) is a serious complication in preterm infants receiving prolonged parenteral nutrition. Soybean lipid emulsion (SLE) seems to have a role in its pathogenesis, whereas fish oil-based emulsion (FOLE) seems to be able to reverse cholestasis. This study aimed to evaluate the effectiveness of a FOLE in reversing PNAC. The effectiveness in reversing PNAC was evaluated in prospective cohort study of very preterm infants when compared to historical controls: twenty-six infants (27.0 ± 2.6 weeks GA; 724 ± 204 g) who developed cholestasis while receiving SLE were shifted to receive FOLE and were compared with 30 infants (27.3 ± 2.5 weeks GA¸ 838 ± 277 g) who continued to receive SLE at diagnosis of cholestasis. Time to reversal of cholestasis was the same in the two study groups (45 ± 21 vs 43 ± 32 days). FOLE does not seem to be superior to SLE in reversing cholestasis. Considering that definitive data on the actual efficacy of FOLE to reverse PNAC are lacking, larger randomized trials are required, mainly to asses if FOLE may have a role in PNAC prevention rather than PNAC treatment.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 47 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 17%
Student > Bachelor 6 13%
Other 5 11%
Researcher 4 9%
Student > Doctoral Student 3 6%
Other 5 11%
Unknown 16 34%
Readers by discipline Count As %
Medicine and Dentistry 13 28%
Nursing and Health Professions 9 19%
Pharmacology, Toxicology and Pharmaceutical Science 3 6%
Agricultural and Biological Sciences 2 4%
Biochemistry, Genetics and Molecular Biology 2 4%
Other 2 4%
Unknown 16 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 August 2018.
All research outputs
#19,954,338
of 25,385,509 outputs
Outputs from Italian Journal of Pediatrics
#698
of 1,060 outputs
Outputs of similar age
#250,785
of 342,525 outputs
Outputs of similar age from Italian Journal of Pediatrics
#15
of 21 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,060 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 342,525 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.