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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Reduced graphene oxide induces transient blood–brain barrier opening: an in vivo study
|
|---|---|
| Published in |
Journal of Nanobiotechnology, October 2015
|
| DOI | 10.1186/s12951-015-0143-z |
| Pubmed ID | |
| Authors |
Monique Culturato Padilha Mendonça, Edilene Siqueira Soares, Marcelo Bispo de Jesus, Helder José Ceragioli, Mônica Siqueira Ferreira, Rodrigo Ramos Catharino, Maria Alice da Cruz-Höfling |
| Abstract |
The blood-brain barrier (BBB) is a complex physical and functional barrier protecting the central nervous system from physical and chemical insults. Nevertheless, it also constitutes a barrier against therapeutics for treating neurological disorders. In this context, nanomaterial-based therapy provides a potential alternative for overcoming this problem. Graphene family has attracted significant interest in nanomedicine because their unique physicochemical properties make them amenable to applications in drug/gene delivery and neural interface. In this study, reduced graphene oxide (rGO) systemically-injected was found mainly located in the thalamus and hippocampus of rats. The entry of rGO involved a transitory decrease in the BBB paracellular tightness, as demonstrated at anatomical (Evans blue dye infusion), subcellular (transmission electron microscopy) and molecular (junctional protein expression) levels. Additionally, we examined the usefulness of matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) as a new imaging method for detecting the temporal distribution of nanomaterials throughout the brain. rGO was able to be detected and monitored in the brain over time provided by a novel application for MALDI-MSI and could be a useful tool for treating a variety of brain disorders that are normally unresponsive to conventional treatment because of BBB impermeability. |
X Demographics
The data shown below were collected from the profiles of 203 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Turkey | 17 | 8% |
| United States | 8 | 4% |
| United Kingdom | 4 | 2% |
| Colombia | 3 | 1% |
| Argentina | 3 | 1% |
| Poland | 3 | 1% |
| Venezuela, Bolivarian Republic of | 3 | 1% |
| Australia | 2 | <1% |
| Spain | 2 | <1% |
| Other | 9 | 4% |
| Unknown | 149 | 73% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 200 | 99% |
| Scientists | 2 | <1% |
| Unknown | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 102 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 22 | 22% |
| Student > Master | 14 | 14% |
| Researcher | 11 | 11% |
| Student > Bachelor | 8 | 8% |
| Student > Doctoral Student | 7 | 7% |
| Other | 14 | 14% |
| Unknown | 26 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 13 | 13% |
| Chemistry | 13 | 13% |
| Agricultural and Biological Sciences | 11 | 11% |
| Neuroscience | 5 | 5% |
| Environmental Science | 5 | 5% |
| Other | 24 | 24% |
| Unknown | 31 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 172. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 April 2024.
All research outputs
#240,917
of 25,808,886 outputs
Outputs from Journal of Nanobiotechnology
#3
of 2,015 outputs
Outputs of similar age
#3,274
of 296,327 outputs
Outputs of similar age from Journal of Nanobiotechnology
#1
of 20 outputs
Altmetric has tracked 25,808,886 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,015 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 296,327 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.