Title |
Outcome analysis of 215 patients with parotid gland tumors: a retrospective cohort analysis
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Published in |
Journal of Otolaryngology - Head & Neck Surgery, October 2015
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DOI | 10.1186/s40463-015-0097-z |
Pubmed ID | |
Authors |
Boban M. Erovic, Manish D. Shah, Guillem Bruch, Meredith Johnston, John Kim, Brian O’Sullivan, Bayardo Perez-Ordonez, Ilan Weinreb, Eshetu G. Atenafu, John R. de Almeida, Patrick J. Gullane, Dale Brown, Ralph W. Gilbert, Jonathan C. Irish, David P. Goldstein |
Abstract |
To identify prognostic factors in patients with parotid gland carcinomas who were treated at the Princess Margaret Hospital. Clinical outcome of two hundred fifteen patients with malignancies of the parotid gland was evaluated over a 16-year period. Two-hundred-fifteen patients with adenoid cystic carcinoma (n = 20), adenocarcinoma (n = 19), acinic cell carcinoma (n = 62), basal cell adenocarcinoma (n = 7), carcinoma-ex-pleomorphic adenoma (n = 18), mucoepidermoid carcinoma (n = 70) and salivary duct carcinoma (n = 19) have been included. The 5- and 10-year overall and disease-free survivals were 80.62 %/69.48 % and 74.37 %/62.42 %, respectively. Multivariable analysis showed that age greater than 60 years, advanced pN classification, histopathological grade and the presence of lymphovascular invasion significantly worsened overall and disease-free survival. Univariable analysis revealed periparotid lymph node involvement was associated with decreased overall (p < 0.0001) and disease-free survival (p < 0.0001). In addition to age, pN classification, histopathological grade, perineural invasion, and lymphovascular involvement, periparotid lymph node metastasis appears to be an important prognosticator in parotid gland malignancy. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 50 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 7 | 14% |
Researcher | 7 | 14% |
Student > Postgraduate | 6 | 12% |
Student > Doctoral Student | 5 | 10% |
Student > Master | 4 | 8% |
Other | 7 | 14% |
Unknown | 14 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 30 | 60% |
Nursing and Health Professions | 2 | 4% |
Biochemistry, Genetics and Molecular Biology | 2 | 4% |
Unknown | 16 | 32% |