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A fat mass and obesity-associated gene polymorphism influences fat mass in exercise-trained individuals

Overview of attention for article published in Journal of the International Society of Sports Nutrition, April 2022
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (52nd percentile)

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Title
A fat mass and obesity-associated gene polymorphism influences fat mass in exercise-trained individuals
Published in
Journal of the International Society of Sports Nutrition, April 2022
DOI 10.1186/s12970-018-0246-7
Pubmed ID
Authors

Jose Antonio, Sarah Knafo, Ritishka Kapoor, Jaime L. Tartar

Abstract

A single nucleotide polymorphism (SNP) in the fat mass and obesity-associated (FTO) gene is a strong predictor of obesity in humans. The FTO SNP (rs1421085) results in a T to C nucleotide substitution that may result in an increased risk for obesity in individuals who carry at least one C allele. The purpose of this investigation was to characterize the FTO genotype in a cohort of exercise-trained men and women. We tested 108 exercise-trained individuals that included professional mixed martial arts fighters, competitive distance runners, collegiate swimmers, stand-up paddlers as well as a cohort of recreational bodybuilders. Body composition was assessed via dual-energy x-ray absorptiometry (DXA). Saliva samples were collected in order to genotype participants and quantify cortisol levels. The physical characteristics of the subjects were as follows (mean±SD): body weight 74.5±15.6 kg; height 171.5±9.5 cm; bone mineral content 2.8±0.7 kg; fat mass 15.7±5.5 kg; lean body mass 55.9±14.4 kg; % body fat 21.6±7.0. Independent samples t tests showed that C allele carriers (n = 54) had significantly higher fat mass t(106) = 3.13, p < 0.01 and body fat percentage t(106) = 2.68, p < 0.01, relative to the TT group (n = 54) (i.e., fat mass: C/- 17.3 ±5.6 kg, TT 14.2±4.6 kg; body fat percentage: C/- group 23.4±7.4%, TT group 19.9±6.2). No other measures of body composition were associated with the FTO genotype (i.e., body mineral density, bone mineral content, or lean body mass). Moreover, cortisol levels were significantly higher in the TT group relative to the C allele carriers t(106) = 2.37, p = 0.02 (i.e., TT 0.35 ±0.35 μg/dL, C/- 0.22±0.16 μg/dL). Our findings demonstrate a relationship between C allele carriers on the FTO gene and a predisposition to a higher fat mass and body fat percentage. In addition, we found no relationship between cortisol and fat mass. However, due to the cross-sectional nature of this investigation, we cannot infer causality regarding the FTO gene and body composition.

X Demographics

X Demographics

The data shown below were collected from the profiles of 28 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 86 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 18 21%
Student > Bachelor 14 16%
Researcher 6 7%
Other 6 7%
Student > Ph. D. Student 6 7%
Other 16 19%
Unknown 20 23%
Readers by discipline Count As %
Sports and Recreations 22 26%
Medicine and Dentistry 13 15%
Agricultural and Biological Sciences 9 10%
Nursing and Health Professions 7 8%
Biochemistry, Genetics and Molecular Biology 6 7%
Other 8 9%
Unknown 21 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 July 2019.
All research outputs
#2,136,099
of 24,089,711 outputs
Outputs from Journal of the International Society of Sports Nutrition
#431
of 911 outputs
Outputs of similar age
#49,632
of 430,108 outputs
Outputs of similar age from Journal of the International Society of Sports Nutrition
#406
of 849 outputs
Altmetric has tracked 24,089,711 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 911 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 61.7. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 430,108 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 849 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.