Title |
The associations between Parkinson’s disease and cancer: the plot thickens
|
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Published in |
Translational Neurodegeneration, October 2015
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DOI | 10.1186/s40035-015-0043-z |
Pubmed ID | |
Authors |
Danielle D. Feng, Waijiao Cai, Xiqun Chen |
Abstract |
Epidemiological studies support a general inverse association between the risk of cancer development and Parkinson's disease (PD). In recent years however, increasing amount of eclectic evidence points to a positive association between PD and cancers through different temporal analyses and ethnic groups. This positive association has been supported by several common genetic mutations in SNCA, PARK2, PARK8, ATM, p53, PTEN, and MC1R resulting in cellular changes such as mitochondrial dysfunction, aberrant protein aggregation, and cell cycle dysregulation. Here, we review the epidemiological and biological advances of the past decade in the association between PD and cancers to offer insight on the recent and sometimes contradictory findings. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 99 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 18 | 18% |
Student > Ph. D. Student | 16 | 16% |
Student > Bachelor | 12 | 12% |
Student > Master | 10 | 10% |
Student > Doctoral Student | 4 | 4% |
Other | 11 | 11% |
Unknown | 28 | 28% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 23 | 23% |
Biochemistry, Genetics and Molecular Biology | 13 | 13% |
Agricultural and Biological Sciences | 12 | 12% |
Neuroscience | 6 | 6% |
Computer Science | 3 | 3% |
Other | 10 | 10% |
Unknown | 32 | 32% |