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3-phase dual-energy CT scan as a feasible salvage imaging modality for the identification of non-localizing parathyroid adenomas: a prospective study

Overview of attention for article published in Journal of Otolaryngology - Head & Neck Surgery, October 2015
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Title
3-phase dual-energy CT scan as a feasible salvage imaging modality for the identification of non-localizing parathyroid adenomas: a prospective study
Published in
Journal of Otolaryngology - Head & Neck Surgery, October 2015
DOI 10.1186/s40463-015-0098-y
Pubmed ID
Authors

Michael Roskies, Xiaoyang Liu, Michael P. Hier, Richard J. Payne, Alex Mlynarek, Veronique Forest, Mark Levental, Reza Forghani

Abstract

Accurate pre-operative imaging of parathyroid adenomas (PAs) is essential for successful minimally invasive surgery; however, rates of non-localizing PAs can be as high as 18 %. Multiphasic dual-energy CT (DECT) has the potential to increase accuracy of PA detection by enabling creation of paired material maps and spectral tissue characterization. This study prospectively evaluated the utility of 3-phase DECT for PA identification in patients with failed localizatio n via standard imaging. Patients with primary hyperparathyroidism and non-localizing PAs underwent a 3 phase post-contrast DECT scan acquired at 25, 55, and 85 s. The scans were prospectively evaluated by two head and neck radiologists. Pre-operative localization was compared to intraoperative localization and final histopathology. A post-hoc DECT spectral density characterization was performed on pathologically-proven PAs. Out of 29 patients with primary hyperparathyroidism and non-localized PAs, DECT identified candidates in 26. Of the 23 patients who underwent parathyroidectomy, DECT provided precise anatomic localization in 20 patients (PPV = 87.0 %), one with multi-gland disease. The virtual unenhanced images were not found to be useful for diagnosis but successful diagnosis was made without an unenhanced phase regardless. Spectral analysis demonstrated a distinct spectral Hounsfield attenuation curve for PAs compared to lymph nodes on arterial phase images. 3-phase DECT without an unenhanced phase is a feasible salvage imaging modality for previously non-localizing parathyroid adenomas. Optimal interpretation is achieved based on a combination of perfusion characteristics and other morphologic features. Advanced spectral DECT analysis has the potential for further increasing accuracy of PA identification in the future.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 10%
Student > Ph. D. Student 3 10%
Researcher 3 10%
Student > Master 3 10%
Lecturer 2 6%
Other 5 16%
Unknown 12 39%
Readers by discipline Count As %
Medicine and Dentistry 10 32%
Engineering 2 6%
Biochemistry, Genetics and Molecular Biology 1 3%
Nursing and Health Professions 1 3%
Physics and Astronomy 1 3%
Other 3 10%
Unknown 13 42%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 November 2015.
All research outputs
#17,348,916
of 25,457,858 outputs
Outputs from Journal of Otolaryngology - Head & Neck Surgery
#321
of 629 outputs
Outputs of similar age
#176,791
of 295,178 outputs
Outputs of similar age from Journal of Otolaryngology - Head & Neck Surgery
#4
of 17 outputs
Altmetric has tracked 25,457,858 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 629 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 295,178 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.