Title |
Tumor microenvironment-responsive nanoparticles for cancer theragnostic applications
|
---|---|
Published in |
Biomaterials Research, August 2018
|
DOI | 10.1186/s40824-018-0132-z |
Pubmed ID | |
Authors |
Saji Uthaman, Kang Moo Huh, In-Kyu Park |
Abstract |
Cancer is one of the deadliest threats to human health. Abnormal physiochemical conditions and dysregulated biosynthetic intermediates in the tumor microenvironment (TME) play a significant role in modulating cancer cells to evade or defend conventional anti-cancer therapy such as surgery, chemotherapy and radiotherapy. One of the most important challenges in the development of anti-tumor therapy is the successful delivery of therapeutic and imaging agents specifically to solid tumors. The recent progresses in development of TME responsive nanoparticles offers promising strategies for combating cancer by making use of the common attributes of tumor such as acidic and hypoxic microenvironments. In this review, we discussed the prominent strategies utilized in the development of tumor microenvironment-responsive nanoparticles and mode of release of therapeutic cargo. Tumor microenvironment-responsive nanoparticles offers a universal approach for anti-cancer therapy. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 175 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 26 | 15% |
Student > Ph. D. Student | 22 | 13% |
Student > Bachelor | 22 | 13% |
Researcher | 14 | 8% |
Student > Doctoral Student | 10 | 6% |
Other | 18 | 10% |
Unknown | 63 | 36% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 23 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 21 | 12% |
Chemistry | 14 | 8% |
Materials Science | 8 | 5% |
Agricultural and Biological Sciences | 7 | 4% |
Other | 26 | 15% |
Unknown | 76 | 43% |