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Changes in gut microbiota and plasma inflammatory factors across the stages of colorectal tumorigenesis: a case-control study

Overview of attention for article published in BMC Microbiology, August 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)

Mentioned by

blogs
1 blog
twitter
3 tweeters

Citations

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39 Dimensions

Readers on

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73 Mendeley
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Title
Changes in gut microbiota and plasma inflammatory factors across the stages of colorectal tumorigenesis: a case-control study
Published in
BMC Microbiology, August 2018
DOI 10.1186/s12866-018-1232-6
Pubmed ID
Authors

Yongzhen Zhang, Xin Yu, Enda Yu, Na Wang, Quancai Cai, Qun Shuai, Feihu Yan, Lufang Jiang, Hexing Wang, Jianxiang Liu, Yue Chen, Zhaoshen Li, Qingwu Jiang

Abstract

Colorectal cancer (CRC) is a common malignant gastrointestinal tumor. In China, CRC is the 5th most commonly diagnosed cancer. The vast majority of CRC cases are sporadic and evolve with the adenoma-carcinoma sequence. There is mounting evidence indicating that gut microbiota and inflammation play important roles in the development of CRC although study results are not entirely consistent. In the current study, we investigated the changes in the CRC-associated bacteria and plasma inflammatory factors and their relationships based on data from a case-control study of Han Chinese. We included 130 initially diagnosed CRC patients, 88 advanced colorectal adenoma patients (A-CRA), 62 patients with benign intestinal polyps and 130 controls. Fecal microbiota composition was obtained using 16S ribosomal DNA (16S rDNA) sequencing. PCOA analysis showed structural differences in microbiota among the four study groups (P = 0.001, Unweighted Unifrac). Twenty-four CRC-associated bacteria were selected by a two-step statistical method and significant correlations were observed within these microbes. CRC-associated bacteria were found to change with the degree of malignancy. Plasma C-reactive protein (CRP) and soluble tumor necrosis factor II (sTNFR-II) displayed significant differences among the four study groups and increased with adenoma-carcinoma sequence. The correlations of CRP and sTNFR-II with several CRC-associated microbes were also explored. CRC-associated species and plasma inflammatory factors tended to change along the adenoma-carcinoma sequence. Several CRC-associated bacteria were correlated with CRP and sTNFR-II. It is likely that gut microbiome and inflammation gradually form a microenvironment that is associated with CRC development.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 73 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 14%
Student > Ph. D. Student 8 11%
Student > Master 8 11%
Student > Bachelor 8 11%
Student > Doctoral Student 6 8%
Other 12 16%
Unknown 21 29%
Readers by discipline Count As %
Medicine and Dentistry 12 16%
Biochemistry, Genetics and Molecular Biology 11 15%
Agricultural and Biological Sciences 9 12%
Immunology and Microbiology 5 7%
Engineering 3 4%
Other 10 14%
Unknown 23 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 September 2018.
All research outputs
#2,072,467
of 13,565,336 outputs
Outputs from BMC Microbiology
#226
of 2,033 outputs
Outputs of similar age
#60,372
of 264,591 outputs
Outputs of similar age from BMC Microbiology
#1
of 1 outputs
Altmetric has tracked 13,565,336 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,033 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,591 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them