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The responsiveness of the EQ-5D and time trade-off scores in schizophrenia, affective disorders, and alcohol addiction

Overview of attention for article published in Health and Quality of Life Outcomes, July 2015
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Title
The responsiveness of the EQ-5D and time trade-off scores in schizophrenia, affective disorders, and alcohol addiction
Published in
Health and Quality of Life Outcomes, July 2015
DOI 10.1186/s12955-015-0315-4
Pubmed ID
Authors

Michael Sonntag, Hans-Helmut König, Alexander Konnopka

Abstract

To compare the responsiveness of the EQ-5D index (German and British tariff), the EQ-5D visual analogue scale (EQ VAS), and time trade-off (TTO) scores in schizophrenia, affective disorders, and alcohol addiction. We used a sample of 502 patients and examined the measures at baseline and after 14 months. We used the generic "WHO Quality of Life BREF" (WHOQOL) and the disorder-specific "Global Severity Index" (GSI) as anchors for a relevant improvement in a patient's health status. In a complete case analysis, we assessed the responsiveness, which is the ability to detect a change given a relevant change on the anchor. We computed the effect sizes (ESs) and standardised response means (SRMs). In patients with schizophrenia, the ESs and SRMs were large (ES/SRM > 0.8) for the British EQ-5D index (ESGSI: 0.93; SRMGSI: 0.89; SRMWHOQOL: 0.82). In patients with affective disorders, we found large ESs and SRMs for the EQ VAS (ESGSI: 1.79; ESWHOQOL: 0.90; SRMGSI: 1.52; SRMWHOQOL: 0.93) and a large ES for the British EQ-5D index (ESGSI: 0.88). In patients with alcohol addiction, the ESs and SRMs were large for the EQ VAS (ESGSI: 1.40; ESWHOQOL: 0.94; SRMGSI: 1.04; SRMWHOQOL: 0.83). The ESs and SRMs of the German EQ-5D index were consistently lower than those of the British EQ-5D index. Regarding TTO score, ESs and SRMs were generally less than 0.5. No preference-based instrument was consistently more responsive than others across all mental disorders. While the EQ VAS was the most responsive instrument in patients with affective disorders or alcohol addiction, the British EQ-5D index was reasonably responsive in patients with schizophrenia.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 45 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 22%
Student > Master 6 13%
Student > Bachelor 5 11%
Student > Ph. D. Student 3 7%
Librarian 2 4%
Other 8 18%
Unknown 11 24%
Readers by discipline Count As %
Medicine and Dentistry 11 24%
Psychology 5 11%
Nursing and Health Professions 2 4%
Social Sciences 2 4%
Economics, Econometrics and Finance 2 4%
Other 7 16%
Unknown 16 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 May 2016.
All research outputs
#20,295,501
of 22,832,057 outputs
Outputs from Health and Quality of Life Outcomes
#1,972
of 2,158 outputs
Outputs of similar age
#219,646
of 262,920 outputs
Outputs of similar age from Health and Quality of Life Outcomes
#58
of 59 outputs
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